The potential of Streptococcus thermophiles (TCI633) in the anti-aging

doi:10.1111/jocd.14445

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/34356

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34356

Title:	The potential of Streptococcus thermophiles (TCI633) in the anti-aging
Authors:	Liu, Cheng Tseng, Ya-Ping Chan, Leong-Perng Liang, Chia-Hua
Contributors:	Dept Hlth & Beauty, Kaoh Dept Optometry Shu Zen Jr Coll Med & Management, Dept Dent Technol Natl Cheng Kung Univ, Inst Basic Med Sci Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Otorhinolaryngol Head & Neck Surg Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg,Fac Med Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
Keywords:	anti-aging skin Streptococcus thermophiles
Date:	2021
Issue Date:	2023-11-11 11:46:36 (UTC+8)
Publisher:	WILEY
Abstract:	Background Streptococcus thermophilus (TCI633) is a probiotic that has been newly isolated from human breast milk, and it can produce hyaluronic acid (HA) when colonizing the gastrointestinal (GI) tract of rodents and humans. A recent study has the established that TCI633 can alleviate synovial tissue inflammation and has potential to mitigate the progression of osteoarthritis. Objective TCI633 has not been available for use in skincare and this preliminary clinical study will assess its improvement of the skin. Methods In this study, DNA protection, Hyaluronidase assay, cell viability, and collagen synthesis on human fibroblasts of TCI633 were assessed. Subjects were enrolled in this clinical study and randomly assigned to the TCI633 or placebo group. Each subject was informed to intake two tablets daily for 8 weeks. Each subject was required to undergo skin condition inspection at weeks 0, 4, and 8 and hematology tests to monitor HA, superoxide dismutase (SOD) and catalase levels, and kidney and liver function at weeks 0 and 8. Results The effects of TCI633 supplementation, including the promotion of skin cell proliferation, the increase of their collagen content, their protection against DNA damage, and the inhibition of hyaluronidase activities, are investigated. Subjects were recruited for an 8-week long clinical trial to confirm the efficacy of TCI633 in improving the serum biochemical HA, SOD and catalase levels, and anti-skin age markers. Conclusions This work provides an alternative approach to improving health, indicating the potential of TCI633 supplementation to delay the aging of skin and improve its condition.
Relation:	J COSMET DERMATOL-US, v.21, n.6, pp.2635-2647
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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