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| 標題: | A Role of CXCL1 Drives Osteosarcoma Lung Metastasis via VCAM-1 Production |
| 作者: | Lee, Chiang-Wen
Chiang, Yao-Chang
Yu, Pei-An
Peng, Kuo-Ti
Chi, Miao-Ching
Lee, Ming-Hsueh
Fang, Mei-Ling
Lee, Kuan-Han
Hsu, Lee-Fen
Liu, Ju-Fang |
| 貢獻者: | Chang Gung Mem Hosp, Dept Orthopaed Surg, Puzi
Chang Gung Univ Sci & Technol, Dept Nursing, Puzi
Chang Gung Univ Sci & Technol, Div Basic Med Sci, Puzi
Chang Gung Univ Sci & Technol, Chron Dis & Hlth Promot Res Ctr, Puzi
Chang Gung Mem Hosp Chia Yi, Sports Med Ctr
Chang Gung Univ, Coll Med
Chang Gung Univ Sci & Technol, Dept Resp Care, Puzi
Chang Gung Mem Hosp, Div Pulm & Crit Care Med
Chang Gung Mem Hosp, Dept Surg, Div Neurosurg
Cheng Shiu Univ, Ctr Environm Toxin & Emerging Contaminant Res
Cheng Shiu Univ, Super Micro Res & Technol Ctr
Chia Nan Univ Pharm & Sci, Dept Pharm
Taipei Med Univ, Coll Oral Med, Sch Oral Hyg
China Med Univ, China Med Univ Hosp, Dept Med Res |
| 關鍵字: | osteosarcoma
metastasis
CXCL1
VCAM-1
migration |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:44:57 (UTC+8) |
| 出版者: | FRONTIERS MEDIA SA |
| 摘要: | Osteosarcoma, a common aggressive and malignant cancer, appears in the musculoskeletal system among young adults. The major cause of mortality in osteosarcoma was the recurrence of lung metastases. However, the molecular mechanisms of metastasis involved in osteosarcomas remain unclear. Recently, CXCL1 and CXCR2 have been crucial indicators for lung metastasis in osteosarcoma by paracrine releases, suggesting the involvement of directing neutrophils into tumor microenvironment. In this study, overexpression of CXCL1 has a positive correlation with the migratory and invasive activities in osteosarcoma cell lines. Furthermore, the signaling pathway, CXCR2/FAK/PI3K/Akt, is activated through CXCL1 by promoting vascular cell adhesion molecule 1 (VCAM-1) via upregulation of nuclear factor-kappa B (NF-kappa B) expression and nuclear translocation. The in vivo animal model further demonstrated that CXCL1 serves as a critical promoter in osteosarcoma metastasis to the lung. The correlated expression of CXCL1 and VCAM-1 was observed in the immunohistochemistry staining from human osteosarcoma specimens. Our findings demonstrate the cascade mechanism regulating the network in lung metastasis osteosarcoma, therefore indicating that the CXCL1/CXCR2 pathway is a worthwhile candidate to further develop treatment schemas. |
| 關聯: | FRONT ONCOL, v.11, pp.735277 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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