A Role of CXCL1 Drives Osteosarcoma Lung Metastasis via VCAM-1 Production

doi:10.3389/fonc.2021.735277

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標題:	A Role of CXCL1 Drives Osteosarcoma Lung Metastasis via VCAM-1 Production
作者:	Lee, Chiang-Wen Chiang, Yao-Chang Yu, Pei-An Peng, Kuo-Ti Chi, Miao-Ching Lee, Ming-Hsueh Fang, Mei-Ling Lee, Kuan-Han Hsu, Lee-Fen Liu, Ju-Fang
貢獻者:	Chang Gung Mem Hosp, Dept Orthopaed Surg, Puzi Chang Gung Univ Sci & Technol, Dept Nursing, Puzi Chang Gung Univ Sci & Technol, Div Basic Med Sci, Puzi Chang Gung Univ Sci & Technol, Chron Dis & Hlth Promot Res Ctr, Puzi Chang Gung Mem Hosp Chia Yi, Sports Med Ctr Chang Gung Univ, Coll Med Chang Gung Univ Sci & Technol, Dept Resp Care, Puzi Chang Gung Mem Hosp, Div Pulm & Crit Care Med Chang Gung Mem Hosp, Dept Surg, Div Neurosurg Cheng Shiu Univ, Ctr Environm Toxin & Emerging Contaminant Res Cheng Shiu Univ, Super Micro Res & Technol Ctr Chia Nan Univ Pharm & Sci, Dept Pharm Taipei Med Univ, Coll Oral Med, Sch Oral Hyg China Med Univ, China Med Univ Hosp, Dept Med Res
關鍵字:	osteosarcoma metastasis CXCL1 VCAM-1 migration
日期:	2021
上傳時間:	2023-11-11 11:44:57 (UTC+8)
出版者:	FRONTIERS MEDIA SA
摘要:	Osteosarcoma, a common aggressive and malignant cancer, appears in the musculoskeletal system among young adults. The major cause of mortality in osteosarcoma was the recurrence of lung metastases. However, the molecular mechanisms of metastasis involved in osteosarcomas remain unclear. Recently, CXCL1 and CXCR2 have been crucial indicators for lung metastasis in osteosarcoma by paracrine releases, suggesting the involvement of directing neutrophils into tumor microenvironment. In this study, overexpression of CXCL1 has a positive correlation with the migratory and invasive activities in osteosarcoma cell lines. Furthermore, the signaling pathway, CXCR2/FAK/PI3K/Akt, is activated through CXCL1 by promoting vascular cell adhesion molecule 1 (VCAM-1) via upregulation of nuclear factor-kappa B (NF-kappa B) expression and nuclear translocation. The in vivo animal model further demonstrated that CXCL1 serves as a critical promoter in osteosarcoma metastasis to the lung. The correlated expression of CXCL1 and VCAM-1 was observed in the immunohistochemistry staining from human osteosarcoma specimens. Our findings demonstrate the cascade mechanism regulating the network in lung metastasis osteosarcoma, therefore indicating that the CXCL1/CXCR2 pathway is a worthwhile candidate to further develop treatment schemas.
關聯:	FRONT ONCOL, v.11, pp.735277
显示于类别:	[藥學系(所)] 期刊論文

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