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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34343


    標題: Ocimum Gratissimum Extract Induces Apoptosis in Gastric Cancer Cells via Modulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase
    作者: Sheu, Ming-Jen
    Tsai, Jen-Ning
    Tam, Wai-Lun
    Liu, Jer-Yuh
    Hsu, Li-Sung
    貢獻者: Chi Mei Med Ctr, Div Gastroenterol & Hepatol
    Chia Nan Univ Pharm & Sci, Dept Med Chem
    Chung Shan Med Univ, Dept Med Lab & Biotechnol
    Chung Shan Med Univ, Inst Med
    China Med Univ, Grad Inst Biomed Sci
    China Med Univ Hosp, Ctr Mol Med
    Chung Shan Med Univ Hosp, Clin Lab
    關鍵字: Apoptosis
    Gastric cancer
    Mitogen-activated protein kinase
    Ocimum gratissimum extract
    Reactive oxygen species
    日期: 2021
    上傳時間: 2023-11-11 11:44:47 (UTC+8)
    出版者: NEW CENTURY HEALTH PUBLISHERS, LLC
    摘要: Given the increasing incidence of gastric cancer and its high rate of metastasis, drug resistance and the mortality rate remain high. Ocimum gratissimum, a botanical species of Ocimum known to exhibit general anti-inflammatory, antioxidant, and anticancer activities has not yet been evaluated for gastric cancer proliferation. In this study, we have demonstrated that O. gratissimum extract significantly reduces the viability of gastric cancer cells by triggering apoptosis, elevating levels of ROS, and enhanced cleavage of poly-ADP-ribose polymerase and caspase-3. Western blot analysis indicated that O. gratissimum extract enhanced the cleavage of PARP and caspase-3. Moreover, O. gratissimum extract inhibited extracellular signal-regulated kinase 1/2 and increased activities of p38, a stress stimulated kinase. In conclusion, our findings show that O. gratissimum extract may be a potential antigastric cancer agent.
    關聯: CURR TOP NUTRACEUT R, v.19, n.4, pp.514-519
    Appears in Collections:[食藥產業暨檢測科技系(含五專)] 期刊論文

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