Ocimum Gratissimum Extract Induces Apoptosis in Gastric Cancer Cells via Modulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase

doi:10.37290/ctnr2641-452X.19:514-519

CNU IR > Pharmacy and Science > Dept. of Food & Drug Industry and Inspective Technology > Periodical Articles > Item 310902800/34343

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34343

Title:	Ocimum Gratissimum Extract Induces Apoptosis in Gastric Cancer Cells via Modulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase
Authors:	Sheu, Ming-Jen Tsai, Jen-Ning Tam, Wai-Lun Liu, Jer-Yuh Hsu, Li-Sung
Contributors:	Chi Mei Med Ctr, Div Gastroenterol & Hepatol Chia Nan Univ Pharm & Sci, Dept Med Chem Chung Shan Med Univ, Dept Med Lab & Biotechnol Chung Shan Med Univ, Inst Med China Med Univ, Grad Inst Biomed Sci China Med Univ Hosp, Ctr Mol Med Chung Shan Med Univ Hosp, Clin Lab
Keywords:	Apoptosis Gastric cancer Mitogen-activated protein kinase Ocimum gratissimum extract Reactive oxygen species
Date:	2021
Issue Date:	2023-11-11 11:44:47 (UTC+8)
Publisher:	NEW CENTURY HEALTH PUBLISHERS, LLC
Abstract:	Given the increasing incidence of gastric cancer and its high rate of metastasis, drug resistance and the mortality rate remain high. Ocimum gratissimum, a botanical species of Ocimum known to exhibit general anti-inflammatory, antioxidant, and anticancer activities has not yet been evaluated for gastric cancer proliferation. In this study, we have demonstrated that O. gratissimum extract significantly reduces the viability of gastric cancer cells by triggering apoptosis, elevating levels of ROS, and enhanced cleavage of poly-ADP-ribose polymerase and caspase-3. Western blot analysis indicated that O. gratissimum extract enhanced the cleavage of PARP and caspase-3. Moreover, O. gratissimum extract inhibited extracellular signal-regulated kinase 1/2 and increased activities of p38, a stress stimulated kinase. In conclusion, our findings show that O. gratissimum extract may be a potential antigastric cancer agent.
Relation:	CURR TOP NUTRACEUT R, v.19, n.4, pp.514-519
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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