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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34156


    標題: Flavopereirine Inhibits Hepatocellular Carcinoma Cell Growth by Inducing Cell-cycle Arrest, Apoptosis, and Autophagy-related Protein Expression
    作者: Chen, San-Yuan
    Chao, Chun-Nun
    Huang, Hsin-Yi
    Fang, Chiung-Yao
    貢獻者: Ditmanson Med Fdn Chiayi Christian Hosp, Dept Chinese Med
    Chia Nan Univ Pharm & Sci, Dept Sports Management
    Ditmanson Med Fdn Chiayi Christian Hosp, Dept Paediat
    Asia Univ, Dept Med Lab Sci & Biotechnol
    Ditmanson Med Fdn Chiayi Christian Hosp, Dept Med Res
    關鍵字: Flavopereirine
    beta-carboline alkaloid
    hepatocarcinoma
    apoptosis
    autophagy
    cell-cycle arrest
    日期: 2020
    上傳時間: 2022-11-18 11:26:20 (UTC+8)
    出版者: Int Inst Anticancer Research
    摘要: Background/Aim: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Resistance to chemotherapy and side-effects remain a challenge for treating advanced and recurrent HCC. Therefore, there is an emerging need to develop new drugs to treat HCC. Materials and Methods: We evaluated the anti-growth activity of flavopereirine in HepG2 and Huh7 HCC cell lines. Cell viability, cell-cycle profile, apoptosis, and autophagy-related protein expressions were analysed after flavopereirine treatment. Results: Flavopereirine treatment induced G(0)/G(1) cell-cycle arrest, with an increase of sub-G1 cells detected at the higher concentration and longer exposure to flavopereirine in HCC cells. Intrinsic and extrinsic pathways were involved in flavopereirine-induced apoptosis, as demonstrated by an increase of cleaved caspase 8 and 9 by western blotting. An alteration of autophagy-related protein expression was also found after flavopereirine treatment. Conclusion: Taken together, the current results indicate that flavopereirine exhibits good anticancer activity in HCC cells.
    關聯: Anticancer Research, v.40, n.12, pp.8
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