Flavopereirine Inhibits Hepatocellular Carcinoma Cell Growth by Inducing Cell-cycle Arrest, Apoptosis, and Autophagy-related Protein Expression

doi:10.21873/anticanres.14714

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標題:	Flavopereirine Inhibits Hepatocellular Carcinoma Cell Growth by Inducing Cell-cycle Arrest, Apoptosis, and Autophagy-related Protein Expression
作者:	Chen, San-Yuan Chao, Chun-Nun Huang, Hsin-Yi Fang, Chiung-Yao
貢獻者:	Ditmanson Med Fdn Chiayi Christian Hosp, Dept Chinese Med Chia Nan Univ Pharm & Sci, Dept Sports Management Ditmanson Med Fdn Chiayi Christian Hosp, Dept Paediat Asia Univ, Dept Med Lab Sci & Biotechnol Ditmanson Med Fdn Chiayi Christian Hosp, Dept Med Res
關鍵字:	Flavopereirine beta-carboline alkaloid hepatocarcinoma apoptosis autophagy cell-cycle arrest
日期:	2020
上傳時間:	2022-11-18 11:26:20 (UTC+8)
出版者:	Int Inst Anticancer Research
摘要:	Background/Aim: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Resistance to chemotherapy and side-effects remain a challenge for treating advanced and recurrent HCC. Therefore, there is an emerging need to develop new drugs to treat HCC. Materials and Methods: We evaluated the anti-growth activity of flavopereirine in HepG2 and Huh7 HCC cell lines. Cell viability, cell-cycle profile, apoptosis, and autophagy-related protein expressions were analysed after flavopereirine treatment. Results: Flavopereirine treatment induced G(0)/G(1) cell-cycle arrest, with an increase of sub-G1 cells detected at the higher concentration and longer exposure to flavopereirine in HCC cells. Intrinsic and extrinsic pathways were involved in flavopereirine-induced apoptosis, as demonstrated by an increase of cleaved caspase 8 and 9 by western blotting. An alteration of autophagy-related protein expression was also found after flavopereirine treatment. Conclusion: Taken together, the current results indicate that flavopereirine exhibits good anticancer activity in HCC cells.
關聯:	Anticancer Research, v.40, n.12, pp.8
显示于类别:	[運動管理系] 期刊論文

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