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https://ir.cnu.edu.tw/handle/310902800/34156
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| 標題: | Flavopereirine Inhibits Hepatocellular Carcinoma Cell Growth by Inducing Cell-cycle Arrest, Apoptosis, and Autophagy-related Protein Expression |
| 作者: | Chen, San-Yuan
Chao, Chun-Nun
Huang, Hsin-Yi
Fang, Chiung-Yao |
| 貢獻者: | Ditmanson Med Fdn Chiayi Christian Hosp, Dept Chinese Med
Chia Nan Univ Pharm & Sci, Dept Sports Management
Ditmanson Med Fdn Chiayi Christian Hosp, Dept Paediat
Asia Univ, Dept Med Lab Sci & Biotechnol
Ditmanson Med Fdn Chiayi Christian Hosp, Dept Med Res |
| 關鍵字: | Flavopereirine
beta-carboline alkaloid
hepatocarcinoma
apoptosis
autophagy
cell-cycle arrest |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:26:20 (UTC+8) |
| 出版者: | Int Inst Anticancer Research |
| 摘要: | Background/Aim: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Resistance to chemotherapy and side-effects remain a challenge for treating advanced and recurrent HCC. Therefore, there is an emerging need to develop new drugs to treat HCC. Materials and Methods: We evaluated the anti-growth activity of flavopereirine in HepG2 and Huh7 HCC cell lines. Cell viability, cell-cycle profile, apoptosis, and autophagy-related protein expressions were analysed after flavopereirine treatment. Results: Flavopereirine treatment induced G(0)/G(1) cell-cycle arrest, with an increase of sub-G1 cells detected at the higher concentration and longer exposure to flavopereirine in HCC cells. Intrinsic and extrinsic pathways were involved in flavopereirine-induced apoptosis, as demonstrated by an increase of cleaved caspase 8 and 9 by western blotting. An alteration of autophagy-related protein expression was also found after flavopereirine treatment. Conclusion: Taken together, the current results indicate that flavopereirine exhibits good anticancer activity in HCC cells. |
| 關聯: | Anticancer Research, v.40, n.12, pp.8 |
| 显示于类别: | [運動管理系] 期刊論文
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