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https://ir.cnu.edu.tw/handle/310902800/34079
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| 標題: | Association between atopic dermatitis and colorectal cancer risk A nationwide cohort study |
| 作者: | Chou, Wan-Yun
Lai, Pin-Yu
Hu, Je-Ming
Hsu, Chih-Hsiung
Chen, Yong-Chen
Tian, Yu-Feng
You, San-Lin
Hsiao, Cheng-Wen
Chou, Yu-Ching
Sun, Chien-An |
| 貢獻者: | Triserv Gen Hosp, Grad Inst Life Sci
Triserv Gen Hosp, Sch Publ Hlth
Triserv Gen Hosp, Grad Inst Med Sci
Triserv Gen Hosp, Dept Surg, Div Colorectal Surg
Natl Def Med Ctr, Sch Med, Triserv Gen Hosp
Natl Def Med Ctr, Triserv Gen Hosp, Teaching Off
Fu Jen Catholic Univ, Dept Med, Coll Med
Fu Jen Catholic Univ, Coll Med, Big Data Res Ctr
Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth |
| 關鍵字: | atopic dermatitis
cohort study
colorectal cancer
National Health Insurance Research Database |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:23:04 (UTC+8) |
| 出版者: | Lippincott Williams & Wilkins |
| 摘要: | The role of atopic dermatitis (AD) in the development of colorectal cancer (CRC) has been a matter of scientific debate with mixed results. We conducted a nationwide cohort study to assess the association between AD and risk of CRC. Drawing on Taiwan's National Health Insurance Research Database, 46,703 patients with AD (the AD cohort) and 186,812 sex, age, and index year-matched patients without AD (the non-AD cohort) were identified in the period between 2000 and 2008. Follow-up time was calculated from the date of entry in the cohort until the occurrence of a first CRC diagnosis, death, or the end of the observation period (December 31, 2013), whichever occurred first. Hazards ratios (HRs) and accompanying 95% confidence intervals (CIs) derived from the Fine-Gray competing risk model were used to estimate the association between AD and CRC risk. After multivariable adjustment, AD was associated with an increased risk of CRC (adjusted HR, 1.26; 95% CI, 1.14-1.40). Of note, a significant positive association between AD and CRC risk was evident in both men and women and in all age groups. In summary, this population-based cohort study revealed that AD was associated with an increased risk of CRC in an Asian population. It will be of interest for cohort studies with prediagnostic specimens to evaluate the potential relationship between AD and CRC using biomarkers for allergy status. |
| 關聯: | Medicine, v.99, n.1, pp.7 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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