Association between atopic dermatitis and colorectal cancer risk A nationwide cohort study

doi:10.1097/MD.0000000000018530

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/34079

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標題:	Association between atopic dermatitis and colorectal cancer risk A nationwide cohort study
作者:	Chou, Wan-Yun Lai, Pin-Yu Hu, Je-Ming Hsu, Chih-Hsiung Chen, Yong-Chen Tian, Yu-Feng You, San-Lin Hsiao, Cheng-Wen Chou, Yu-Ching Sun, Chien-An
貢獻者:	Triserv Gen Hosp, Grad Inst Life Sci Triserv Gen Hosp, Sch Publ Hlth Triserv Gen Hosp, Grad Inst Med Sci Triserv Gen Hosp, Dept Surg, Div Colorectal Surg Natl Def Med Ctr, Sch Med, Triserv Gen Hosp Natl Def Med Ctr, Triserv Gen Hosp, Teaching Off Fu Jen Catholic Univ, Dept Med, Coll Med Fu Jen Catholic Univ, Coll Med, Big Data Res Ctr Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth
關鍵字:	atopic dermatitis cohort study colorectal cancer National Health Insurance Research Database
日期:	2020
上傳時間:	2022-11-18 11:23:04 (UTC+8)
出版者:	Lippincott Williams & Wilkins
摘要:	The role of atopic dermatitis (AD) in the development of colorectal cancer (CRC) has been a matter of scientific debate with mixed results. We conducted a nationwide cohort study to assess the association between AD and risk of CRC. Drawing on Taiwan's National Health Insurance Research Database, 46,703 patients with AD (the AD cohort) and 186,812 sex, age, and index year-matched patients without AD (the non-AD cohort) were identified in the period between 2000 and 2008. Follow-up time was calculated from the date of entry in the cohort until the occurrence of a first CRC diagnosis, death, or the end of the observation period (December 31, 2013), whichever occurred first. Hazards ratios (HRs) and accompanying 95% confidence intervals (CIs) derived from the Fine-Gray competing risk model were used to estimate the association between AD and CRC risk. After multivariable adjustment, AD was associated with an increased risk of CRC (adjusted HR, 1.26; 95% CI, 1.14-1.40). Of note, a significant positive association between AD and CRC risk was evident in both men and women and in all age groups. In summary, this population-based cohort study revealed that AD was associated with an increased risk of CRC in an Asian population. It will be of interest for cohort studies with prediagnostic specimens to evaluate the potential relationship between AD and CRC using biomarkers for allergy status.
關聯:	Medicine, v.99, n.1, pp.7
显示于类别:	[保健營養系(所) ] 期刊論文

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