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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34074


    標題: Anticancer activity and mediation of apoptosis in hepatoma carcinoma cells induced by djulis and its bioactive compounds
    作者: Chu, Chin-Chen
    Chen, Shih-Ying
    Chyau, Charng-Cherng
    Wu, You-Chia
    Chu, Heuy-Ling
    Duh, Pin -Der
    貢獻者: Chi Mei Med Ctr, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Hungkuang Univ, Res Inst Biotechnol
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    關鍵字: Anticancer activity
    Chemopreventive agent
    Djulis
    Hepatoma carcinoma cells
    Quercetin
    日期: 2020
    上傳時間: 2022-11-18 11:22:51 (UTC+8)
    出版者: Elsevier
    摘要: Anticancer activity and mediation of apoptosis in hepatoma carcinoma cells induced by ethanolic extracts of djulis (EECF) and its bioactive compounds were investigated. EECF (50-500 mu g/ml) exhibited significant cytotoxicity in HepG2 cells. AnnexinV-FITC/PI and DAPI staining assay showed that EECF induced apoptosis, accompanied with Sub-G0 phase arrest, ROS generation, loss of mitochondrial membrane potential (Delta Psi m), increase of Bax/Bcl-2 ratio, caspase-3 activation and PARP cleavage. According to the HPLC-DAD and HPLC-MS/ MS analysis, betanin, rutin, kaempferol, and quercetin were present in EECF, and showed antiproliferative action in HepG2 cells. Among the four bioactive compounds, quercetin showed the highest apoptotic effect toward HepG2 cells. In vivo, EECF and quercetin significantly reduced tumor growth in nude mice in tumor xenografts of HepG2 cells. Overall, the presence of bioactive compounds in EECF may account for the anticancer activity of EECF, and EECF could act as a potential chemopreventive agent against growth of hepatoma carcinoma cells.
    關聯: Journal of Functional Foods, v.75, pp.12
    Appears in Collections:[保健營養系(所) ] 期刊論文
    [ 食品科技系 ] 期刊論文

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