English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17744/20032 (89%)
Visitors : 7329454      Online Users : 259
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32709

    標題: Chlorpheniramine produces cutaneous analgesia in rats
    作者: Chiu, Chong-Chi
    Kuo-Sheng Liu(劉國盛)
    Chen, Yu-Wen
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: Chi Mei Med Ctr, Dept Gen Surg
    Southern Taiwan Univ Sci & Technol, Dept Elect Engn
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chi Mei Med Ctr, Dept Med Res
    China Med Univ, Coll Hlth Care, Dept Phys Therapy
    Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy, 1 Ta Hsueh Rd
    Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
    Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr
    關鍵字: Chlorpheniramine
    Infiltrative cutaneous analgesia
    Needle pinprick
    日期: 2019-08
    上傳時間: 2020-08-25 15:07:45 (UTC+8)
    摘要: Background This study sought to assess the cutaneous (peripheral) analgesic effects of antihistamine chlorpheniramine, compared with the long-lasting local anesthetic bupivacaine. Methods After chlorpheniramine and bupivacaine were subcutaneously injected under the dorsal skin of the rats, the cutaneous analgesia effect was quantitatively evaluated by scoring the number to which the animal failed to react (cutaneous trunci muscle reflex). The quality and duration of chlorpheniramine and bupivacaine on infiltrative cutaneous analgesia were compared. Results We revealed that subcutaneous chlorpheniramine, as well as the local anesthetic bupivacaine elicited cutaneous analgesia in a dosage-dependent manner. Based on their ED(50)s (50% effective doses), the relative potency was found to be chlorpheniramine [1.13 (1.05-1.22) mu mol] < bupivacaine [0.52 (0.46-0.58) mu mol] (p < 0.01). When comparing the ED(25)s, ED(50)s and ED(75)s, full recovery time induced by chlorpheniramine was longer (p < 0.01) than that induced by bupivacaine. Conclusions Our preclinical data demonstrated that both chlorpheniramine and bupivacaine dose-dependently provoked the cutaneous analgesic effects. Chlorpheniramine with a more prolonged duration was less potent than bupivacaine in inducing cutaneous analgesia.
    關聯: Pharmacological Reports, v.72, n.4, pp.827-832
    Appears in Collections:[藥學系(所)] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback