Chlorpheniramine produces cutaneous analgesia in rats

doi:10.1007/s43440-019-00028-7

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/32709

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Title:	Chlorpheniramine produces cutaneous analgesia in rats
Authors:	Chiu, Chong-Chi Kuo-Sheng Liu(劉國盛) Chen, Yu-Wen Hung, Ching-Hsia Wang, Jhi-Joung
Contributors:	Chi Mei Med Ctr, Dept Gen Surg Southern Taiwan Univ Sci & Technol, Dept Elect Engn Chia Nan Univ Pharm & Sci, Dept Pharm Chi Mei Med Ctr, Dept Med Res China Med Univ, Coll Hlth Care, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy, 1 Ta Hsueh Rd Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr
Keywords:	Chlorpheniramine Bupivacaine Infiltrative cutaneous analgesia Needle pinprick
Date:	2019-08
Issue Date:	2020-08-25 15:07:45 (UTC+8)
Publisher:	SPRINGER HEIDELBERG
Abstract:	Background This study sought to assess the cutaneous (peripheral) analgesic effects of antihistamine chlorpheniramine, compared with the long-lasting local anesthetic bupivacaine. Methods After chlorpheniramine and bupivacaine were subcutaneously injected under the dorsal skin of the rats, the cutaneous analgesia effect was quantitatively evaluated by scoring the number to which the animal failed to react (cutaneous trunci muscle reflex). The quality and duration of chlorpheniramine and bupivacaine on infiltrative cutaneous analgesia were compared. Results We revealed that subcutaneous chlorpheniramine, as well as the local anesthetic bupivacaine elicited cutaneous analgesia in a dosage-dependent manner. Based on their ED(50)s (50% effective doses), the relative potency was found to be chlorpheniramine [1.13 (1.05-1.22) mu mol] < bupivacaine [0.52 (0.46-0.58) mu mol] (p < 0.01). When comparing the ED(25)s, ED(50)s and ED(75)s, full recovery time induced by chlorpheniramine was longer (p < 0.01) than that induced by bupivacaine. Conclusions Our preclinical data demonstrated that both chlorpheniramine and bupivacaine dose-dependently provoked the cutaneous analgesic effects. Chlorpheniramine with a more prolonged duration was less potent than bupivacaine in inducing cutaneous analgesia.
Relation:	Pharmacological Reports, v.72, n.4, pp.827-832
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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