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| 標題: | Timing of follow-up blood cultures for community-onset bacteremia |
| 作者: | Lee, Ching-Chi
Yang, Chao-Yung
Hsieh, Chih-Chia
Hong, Ming-Yuan
Lee, Chung-Hsun
Hung-Jen Tang(湯宏仁)
Ko, Wen-Chien |
| 貢獻者: | Tainan Sin Lau Hosp, Dept Adult Crit Care Med
Chang Jung Christian Univ, Coll Hlth Sci, Grad Inst Med Sci
Natl Cheng Kung Univ Hosp, Dept Emergency Med, Tainan, Taiwan
Natl Cheng Kung Univ, Med Coll, Dept Med
Chi Mei Med Ctr, Dept Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Natl Cheng Kung Univ Hosp, Dept Internal Med |
| 關鍵字: | GRAM-NEGATIVE BACTEREMIA
OUTCOMES
ISSUES
ADULTS |
| 日期: | 2019-10 |
| 上傳時間: | 2020-07-29 13:54:46 (UTC+8) |
| 出版者: | NATURE PUBLISHING GROUP |
| 摘要: | Bacteremia is associated with high morbidity and mortality, but the utility and optimal timing of follow-up blood cultures (FUBCs) remain undefined. To assess the optimal timing of FUBCs related to appropriate antibiotic therapy (AAT), adults with community-onset bacteremia and FUBCs after bacteremia onset were retrospectively studied during the 6-year period in two hospitals. Based on the time gap between the initiation of AAT and FUBC sampling, 1,247 eligible patients were categorized as FUBCs prior to AAT (65 patients, 5.2%), 0-3 days (202, 16.2%), 3.1-6 days (470, 37.7%), 6.1-9 days (299, 24.0%), and >= 9 days (211, 16.9%) after AAT. The prognostic impact of the growth of the same bacteria in FUBCs on 30-day mortality was evidenced only in patients with FUBCs at 3.1-6 days after AAT (adjusted odds ratio [AOR], 3.75; P < 0.001), not in those with FUBCs prior to AAT (AOR, 2.86; P= 0.25), 0-3 days (AOR, 0.39; P= 0.08), 6.1-9 days (AOR, 2.19; P= 0.32), and >= 9 days (AOR, 0.41; P= 0.41) of AAT, after adjusting independent factors of 30-day mortality recognized by the multivariable regression in each category. Conclusively, persistent bacteremia in FUBCs added prognostic significance in the management of adults with community-onset bacteremia after 3.1-6 days of AAT. |
| 關聯: | Scientific Reports, v.9, 14500 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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| 10.1038-s41598-019-51032-z.pdf | | 1209Kb | Adobe PDF | 330 | 檢視/開啟 | | index.html | | 0Kb | HTML | 1160 | 檢視/開啟 |
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