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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32674


    標題: Timing of follow-up blood cultures for community-onset bacteremia
    作者: Lee, Ching-Chi
    Yang, Chao-Yung
    Hsieh, Chih-Chia
    Hong, Ming-Yuan
    Lee, Chung-Hsun
    Hung-Jen Tang(湯宏仁)
    Ko, Wen-Chien
    貢獻者: Tainan Sin Lau Hosp, Dept Adult Crit Care Med
    Chang Jung Christian Univ, Coll Hlth Sci, Grad Inst Med Sci
    Natl Cheng Kung Univ Hosp, Dept Emergency Med, Tainan, Taiwan
    Natl Cheng Kung Univ, Med Coll, Dept Med
    Chi Mei Med Ctr, Dept Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Natl Cheng Kung Univ Hosp, Dept Internal Med
    關鍵字: GRAM-NEGATIVE BACTEREMIA
    OUTCOMES
    ISSUES
    ADULTS
    日期: 2019-10
    上傳時間: 2020-07-29 13:54:46 (UTC+8)
    出版者: NATURE PUBLISHING GROUP
    摘要: Bacteremia is associated with high morbidity and mortality, but the utility and optimal timing of follow-up blood cultures (FUBCs) remain undefined. To assess the optimal timing of FUBCs related to appropriate antibiotic therapy (AAT), adults with community-onset bacteremia and FUBCs after bacteremia onset were retrospectively studied during the 6-year period in two hospitals. Based on the time gap between the initiation of AAT and FUBC sampling, 1,247 eligible patients were categorized as FUBCs prior to AAT (65 patients, 5.2%), 0-3 days (202, 16.2%), 3.1-6 days (470, 37.7%), 6.1-9 days (299, 24.0%), and >= 9 days (211, 16.9%) after AAT. The prognostic impact of the growth of the same bacteria in FUBCs on 30-day mortality was evidenced only in patients with FUBCs at 3.1-6 days after AAT (adjusted odds ratio [AOR], 3.75; P < 0.001), not in those with FUBCs prior to AAT (AOR, 2.86; P= 0.25), 0-3 days (AOR, 0.39; P= 0.08), 6.1-9 days (AOR, 2.19; P= 0.32), and >= 9 days (AOR, 0.41; P= 0.41) of AAT, after adjusting independent factors of 30-day mortality recognized by the multivariable regression in each category. Conclusively, persistent bacteremia in FUBCs added prognostic significance in the management of adults with community-onset bacteremia after 3.1-6 days of AAT.
    關聯: Scientific Reports, v.9, 14500
    Appears in Collections:[保健營養系(所) ] 期刊論文

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