Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM

doi:10.1371/journal.pone.0225978

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標題:	Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
作者:	Yen, I-Weng Lee, Chien-Nan Lin, Ming-Wei Fan, Kang-Chih Jung-Nan Wei(魏榮男) Chen, Kuan-Yu Chen, Szu-Chi Tai, Yi-Yun Kuo, Chun-Heng Lin, Chia-Hung Hsu, Chih-Yao Chuang, Lee-Ming Lin, Shin-Yu Li, Hung-Yuan
貢獻者:	Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch, Hsinchu, Taiwan Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Taipei, Taiwan Chia Nan Univ Pharm & Sci, Tainan, Taiwan Ansn Clin, Hsinchu, Taiwan Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan Fu Jen Catholic Univ Hosp, Dept Internal Med, New Taipei, Taiwan Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
關鍵字:	BODY-MASS INDEX INSULIN INFLAMMATION
日期:	2019-12
上傳時間:	2020-07-29 13:54:35 (UTC+8)
出版者:	PUBLIC LIBRARY SCIENCE
摘要:	Aim Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. Methods Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index.24 kg/m(2). GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24-28 gestational weeks. Results Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p< 0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p < 0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women. Conclusions Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women.
關聯:	Plos One, v.14, n.12, e0225978
显示于类别:	[職業安全衛生系(含防災所)] 期刊論文

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