Expression of prothymosin in lung cancer is associated with squamous cell carcinoma and smoking

doi:10.3892/ol.2019.10248

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/32635

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標題:	Expression of prothymosin in lung cancer is associated with squamous cell carcinoma and smoking
作者:	Yu-Hsuan Kuo(郭雨萱) Shiau, Ai-Li Tung, Chao-Ling Su, Yu-Chu Li, Chien-Feng Su, Bing-Hua Tsao, Chao-Jung Wu, Chao-Liang Feng, Yin-Hsun Wu, Pensee
貢獻者:	Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol Chia Nan Univ, Coll Pharm & Sci Natl Cheng Kung Univ, Med Coll, Dept Microbiol & Immunol Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Med Coll, Dept Otolaryngol Chi Mei Med Ctr, Dept Pathol Natl Cheng Kung Univ, Med Coll, Dept Biochem & Mol Biol Chi Mei Med Ctr, Div Hematol & Oncol Chung Hwa Univ Med Technol, Dept Nursing Imperial Coll London, Inst Reprod & Dev Biol
關鍵字:	prothymosin lung cancer squamous cell carcinoma cigarettes
日期:	2019-06
上傳時間:	2020-07-29 13:53:07 (UTC+8)
出版者:	SPANDIDOS PUBL LTD
摘要:	Prothymosin (ProT) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProT expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProT-positive lung cancer. Immunohistochemical staining of ProT was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProT and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProT-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProT-positive by scoring index. The majority of patients with ProT-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProT by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProT expression. ProT was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProT-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.
關聯:	Oncology Letters, v.17, n.6, pp.5740-5746
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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