Expression of prothymosin in lung cancer is associated with squamous cell carcinoma and smoking

doi:10.3892/ol.2019.10248

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/32635

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32635

Title:	Expression of prothymosin in lung cancer is associated with squamous cell carcinoma and smoking
Authors:	Yu-Hsuan Kuo(郭雨萱) Shiau, Ai-Li Tung, Chao-Ling Su, Yu-Chu Li, Chien-Feng Su, Bing-Hua Tsao, Chao-Jung Wu, Chao-Liang Feng, Yin-Hsun Wu, Pensee
Contributors:	Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol Chia Nan Univ, Coll Pharm & Sci Natl Cheng Kung Univ, Med Coll, Dept Microbiol & Immunol Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Med Coll, Dept Otolaryngol Chi Mei Med Ctr, Dept Pathol Natl Cheng Kung Univ, Med Coll, Dept Biochem & Mol Biol Chi Mei Med Ctr, Div Hematol & Oncol Chung Hwa Univ Med Technol, Dept Nursing Imperial Coll London, Inst Reprod & Dev Biol
Keywords:	prothymosin lung cancer squamous cell carcinoma cigarettes
Date:	2019-06
Issue Date:	2020-07-29 13:53:07 (UTC+8)
Publisher:	SPANDIDOS PUBL LTD
Abstract:	Prothymosin (ProT) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProT expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProT-positive lung cancer. Immunohistochemical staining of ProT was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProT and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProT-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProT-positive by scoring index. The majority of patients with ProT-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProT by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProT expression. ProT was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProT-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.
Relation:	Oncology Letters, v.17, n.6, pp.5740-5746
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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