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| 標題: | Expression of prothymosin in lung cancer is associated with squamous cell carcinoma and smoking |
| 作者: | Yu-Hsuan Kuo(郭雨萱)
Shiau, Ai-Li
Tung, Chao-Ling
Su, Yu-Chu
Li, Chien-Feng
Su, Bing-Hua
Tsao, Chao-Jung
Wu, Chao-Liang
Feng, Yin-Hsun
Wu, Pensee |
| 貢獻者: | Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol
Chia Nan Univ, Coll Pharm & Sci
Natl Cheng Kung Univ, Med Coll, Dept Microbiol & Immunol
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Med Coll, Dept Otolaryngol
Chi Mei Med Ctr, Dept Pathol
Natl Cheng Kung Univ, Med Coll, Dept Biochem & Mol Biol
Chi Mei Med Ctr, Div Hematol & Oncol
Chung Hwa Univ Med Technol, Dept Nursing
Imperial Coll London, Inst Reprod & Dev Biol |
| 關鍵字: | prothymosin
lung cancer
squamous cell carcinoma
cigarettes |
| 日期: | 2019-06 |
| 上傳時間: | 2020-07-29 13:53:07 (UTC+8) |
| 出版者: | SPANDIDOS PUBL LTD |
| 摘要: | Prothymosin (ProT) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProT expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProT-positive lung cancer. Immunohistochemical staining of ProT was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProT and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProT-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProT-positive by scoring index. The majority of patients with ProT-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProT by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProT expression. ProT was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProT-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes. |
| 關聯: | Oncology Letters, v.17, n.6, pp.5740-5746 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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