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https://ir.cnu.edu.tw/handle/310902800/32592
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| 標題: | Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals |
| 作者: | Wang, Lai-Hao(王來好)
Cheng, Pei-Tung |
| 貢獻者: | Chia Nan Univ Pharm & Sci, Dept Med Chem |
| 關鍵字: | Hair-growth pharmaceuticals
minoxidil
voltammetric sensor
gold (Au)
glassy carbon (GCEs)
carbon paste electrodes (CPEs) |
| 日期: | 2019 |
| 上傳時間: | 2020-07-29 13:51:13 (UTC+8) |
| 出版者: | BENTHAM SCIENCE PUBL LTD |
| 摘要: | Background: The electrochemical behavior of minoxidil on gold (Au), Glassy Carbon (GCEs), and Carbon Paste Electrodes (CPEs) was investigated in an aqueous supporting electrolyte (phosphate buffer [pH 2.0-6.5], acetate buffer [pH 4.3], and Britton and Robinson buffer [pH 2.0-7.4]). Methods: For cyclic voltammetric measurements with suitable methodical parameters, CPEs catalyze electrooxidation of minoxidil more efficiently than do other electrodes. Minoxidil was detected using high-performance liquid chromatography with an electrochemical (carbon paste) detector (HPLC-ECD). For direct current mode, with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration from 0.02 to 2.6 mg L-1 was found. The detection limit was approximately 20 ng m L-1. Results: The developed method detected minoxidil samples. Conclusion: Findings using HPLC-ECD and HPLC with an ultraviolet detector were comparable. |
| 關聯: | Current Analytical Chemistry, v.15, n.5, pp.575-582 |
| 顯示於類別: | [食藥產業暨檢測科技系(含五專)] 期刊論文
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