Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals

doi:10.2174/1573411014666180731120746

CNU IR > Pharmacy and Science > Dept. of Food & Drug Industry and Inspective Technology > Periodical Articles > Item 310902800/32592

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题名:	Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals
作者:	Wang, Lai-Hao(王來好) Cheng, Pei-Tung
贡献者:	Chia Nan Univ Pharm & Sci, Dept Med Chem
关键词:	Hair-growth pharmaceuticals minoxidil voltammetric sensor gold (Au) glassy carbon (GCEs) carbon paste electrodes (CPEs)
日期:	2019
上传时间:	2020-07-29 13:51:13 (UTC+8)
出版者:	BENTHAM SCIENCE PUBL LTD
摘要:	Background: The electrochemical behavior of minoxidil on gold (Au), Glassy Carbon (GCEs), and Carbon Paste Electrodes (CPEs) was investigated in an aqueous supporting electrolyte (phosphate buffer [pH 2.0-6.5], acetate buffer [pH 4.3], and Britton and Robinson buffer [pH 2.0-7.4]). Methods: For cyclic voltammetric measurements with suitable methodical parameters, CPEs catalyze electrooxidation of minoxidil more efficiently than do other electrodes. Minoxidil was detected using high-performance liquid chromatography with an electrochemical (carbon paste) detector (HPLC-ECD). For direct current mode, with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration from 0.02 to 2.6 mg L-1 was found. The detection limit was approximately 20 ng m L-1. Results: The developed method detected minoxidil samples. Conclusion: Findings using HPLC-ECD and HPLC with an ultraviolet detector were comparable.
關聯:	Current Analytical Chemistry, v.15, n.5, pp.575-582
显示于类别:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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