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| 標題: | Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production |
| 作者: | Liao, Hung-Wei
Huang, Tsang-Hai
Chang, Yi-Han
Liou, Hung-Hsiang
Chou, Yu-Hsien
Sue, Yuh-Mou
Peir-Haur Hung(洪培豪)
Chang, Yu-Tzu
Ho, Pei-Chuan
Tsai, Kuen-Jer |
| 貢獻者: | Chinru Clin
Natl Cheng Kung Univ, Inst Phys Educ Hlth & Leisure Studies
Natl Cheng Kung Univ, Coll Med, Inst Clin Med
Hsin Jen Hosp, Dept Med, Div Nephrol
Taipei Med Univ, Coll Med, Sch Med, Div Nephrol,Dept Internal Med
Taipei Med Univ, Wan Fang Hosp
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med
Chia Nan Univ Pharm & Sci, Div Appl Life Sci & Hlth
Natl Cheng Kung Univ, Coll Med, Dept Internal Med
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Res Ctr Clin Med |
| 關鍵字: | exercise
chronic kidney disease
osteoporosis
sclerostin
chronic kidney disease-mineral bone disorder |
| 日期: | 2019-04 |
| 上傳時間: | 2020-07-29 13:50:38 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Chronic kidney disease-mineral bone disorder (CKD-MBD), comprising mineral, hormonal, and bone metabolic imbalance, is a major CKD-related issue; it causes osteoporosis prevalence in CKD patients. Osteocyte-derived sclerostin inhibits the osteogenic Wnt/-catenin signaling pathway; its levels rise when kidney function declines. Exercise modulates the physiological functions of osteocytes, potentially altering sclerostin production. It may aid bone and mineral electrolyte homeostasis in CKD. Mild CKD was induced in rats by partial nephrectomy. They were divided into: sham (no CKD), CKD, and CKD + exercise (8 weeks of treadmill running) groups. Micro-CT scanning demonstrated that the CKD + exercise-group rats had a higher bone mineral density (BMD) of the spine and femoral metaphysis and higher femoral trabecular bone volume than the CKD-group rats. Bone formation rates were not significantly different. The CKD + exercise-group rats had lower serum sclerostin (157.1 +/- 21.1 vs 309 +/- 38.1 pg/mL, p < 0.05) and CTX-1 (bone resorption marker) levels. Immunohistochemistry revealed higher tibial -catenin concentrations in the CKD + exercise-group rats. Serum FGF-23, intact parathyroid hormone (iPTH), alkaline phosphatase (ALP), calcium, and phosphate levels showed no significant differences between these groups. Thus, exercise improves BMD and bone microstructure in mild CKD by inhibiting sclerostin production, but does not alter serum minerals. |
| 關聯: | International Journal of Molecular Sciences, v.20, n.8, 2044 |
| 顯示於類別: | [生活保健科技系] 期刊論文
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