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    標題: Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production
    作者: Liao, Hung-Wei
    Huang, Tsang-Hai
    Chang, Yi-Han
    Liou, Hung-Hsiang
    Chou, Yu-Hsien
    Sue, Yuh-Mou
    Peir-Haur Hung(洪培豪)
    Chang, Yu-Tzu
    Ho, Pei-Chuan
    Tsai, Kuen-Jer
    貢獻者: Chinru Clin
    Natl Cheng Kung Univ, Inst Phys Educ Hlth & Leisure Studies
    Natl Cheng Kung Univ, Coll Med, Inst Clin Med
    Hsin Jen Hosp, Dept Med, Div Nephrol
    Taipei Med Univ, Coll Med, Sch Med, Div Nephrol,Dept Internal Med
    Taipei Med Univ, Wan Fang Hosp
    Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Div Appl Life Sci & Hlth
    Natl Cheng Kung Univ, Coll Med, Dept Internal Med
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Res Ctr Clin Med
    關鍵字: exercise
    chronic kidney disease
    osteoporosis
    sclerostin
    chronic kidney disease-mineral bone disorder
    日期: 2019-04
    上傳時間: 2020-07-29 13:50:38 (UTC+8)
    出版者: MDPI
    摘要: Chronic kidney disease-mineral bone disorder (CKD-MBD), comprising mineral, hormonal, and bone metabolic imbalance, is a major CKD-related issue; it causes osteoporosis prevalence in CKD patients. Osteocyte-derived sclerostin inhibits the osteogenic Wnt/-catenin signaling pathway; its levels rise when kidney function declines. Exercise modulates the physiological functions of osteocytes, potentially altering sclerostin production. It may aid bone and mineral electrolyte homeostasis in CKD. Mild CKD was induced in rats by partial nephrectomy. They were divided into: sham (no CKD), CKD, and CKD + exercise (8 weeks of treadmill running) groups. Micro-CT scanning demonstrated that the CKD + exercise-group rats had a higher bone mineral density (BMD) of the spine and femoral metaphysis and higher femoral trabecular bone volume than the CKD-group rats. Bone formation rates were not significantly different. The CKD + exercise-group rats had lower serum sclerostin (157.1 +/- 21.1 vs 309 +/- 38.1 pg/mL, p < 0.05) and CTX-1 (bone resorption marker) levels. Immunohistochemistry revealed higher tibial -catenin concentrations in the CKD + exercise-group rats. Serum FGF-23, intact parathyroid hormone (iPTH), alkaline phosphatase (ALP), calcium, and phosphate levels showed no significant differences between these groups. Thus, exercise improves BMD and bone microstructure in mild CKD by inhibiting sclerostin production, but does not alter serum minerals.
    關聯: International Journal of Molecular Sciences, v.20, n.8, 2044
    Appears in Collections:[生活應用與保健系] 期刊論文

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