Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production

doi:10.3390/ijms20082044

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Title:	Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production
Authors:	Liao, Hung-Wei Huang, Tsang-Hai Chang, Yi-Han Liou, Hung-Hsiang Chou, Yu-Hsien Sue, Yuh-Mou Peir-Haur Hung(洪培豪) Chang, Yu-Tzu Ho, Pei-Chuan Tsai, Kuen-Jer
Contributors:	Chinru Clin Natl Cheng Kung Univ, Inst Phys Educ Hlth & Leisure Studies Natl Cheng Kung Univ, Coll Med, Inst Clin Med Hsin Jen Hosp, Dept Med, Div Nephrol Taipei Med Univ, Coll Med, Sch Med, Div Nephrol,Dept Internal Med Taipei Med Univ, Wan Fang Hosp Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med Chia Nan Univ Pharm & Sci, Div Appl Life Sci & Hlth Natl Cheng Kung Univ, Coll Med, Dept Internal Med Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Res Ctr Clin Med
Keywords:	exercise chronic kidney disease osteoporosis sclerostin chronic kidney disease-mineral bone disorder
Date:	2019-04
Issue Date:	2020-07-29 13:50:38 (UTC+8)
Publisher:	MDPI
Abstract:	Chronic kidney disease-mineral bone disorder (CKD-MBD), comprising mineral, hormonal, and bone metabolic imbalance, is a major CKD-related issue; it causes osteoporosis prevalence in CKD patients. Osteocyte-derived sclerostin inhibits the osteogenic Wnt/-catenin signaling pathway; its levels rise when kidney function declines. Exercise modulates the physiological functions of osteocytes, potentially altering sclerostin production. It may aid bone and mineral electrolyte homeostasis in CKD. Mild CKD was induced in rats by partial nephrectomy. They were divided into: sham (no CKD), CKD, and CKD + exercise (8 weeks of treadmill running) groups. Micro-CT scanning demonstrated that the CKD + exercise-group rats had a higher bone mineral density (BMD) of the spine and femoral metaphysis and higher femoral trabecular bone volume than the CKD-group rats. Bone formation rates were not significantly different. The CKD + exercise-group rats had lower serum sclerostin (157.1 +/- 21.1 vs 309 +/- 38.1 pg/mL, p < 0.05) and CTX-1 (bone resorption marker) levels. Immunohistochemistry revealed higher tibial -catenin concentrations in the CKD + exercise-group rats. Serum FGF-23, intact parathyroid hormone (iPTH), alkaline phosphatase (ALP), calcium, and phosphate levels showed no significant differences between these groups. Thus, exercise improves BMD and bone microstructure in mild CKD by inhibiting sclerostin production, but does not alter serum minerals.
Relation:	International Journal of Molecular Sciences, v.20, n.8, 2044
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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