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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32556

    標題: The impact of marital status on survival in patients with surgically treated colon cancer
    作者: Ching-Chieh Yang(楊清傑)
    Cheng, Li-Chin
    Lin, Yu-Wei
    Wang, Shih-Chang
    Ke, Te-Min
    Huang, Chung-I.
    Su, Yu-Chieh
    Tai, Ming-Hong
    貢獻者: Chi Mei Med Ctr, Dept Radiat Oncol
    Natl Sun Yat Sen Univ, Inst Biomed Sci
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chi Mei Med Ctr, Div Colorectal Surg
    E Da Canc Hosp, Dept Radiat Oncol
    Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol
    Kaohsiung Med Univ, Coll Med, Fac Med
    Natl Sun Yat Sen Univ, Ctr Neurosci
    關鍵字: colon cancer
    marital status
    日期: 2019-03
    上傳時間: 2020-07-29 13:49:46 (UTC+8)
    摘要: The aim of this study was to investigate the relationship between marital status and disease outcome in patients with surgically treated colon cancer. Between June 2010 and December 2015, a total of 925 patients with newly diagnosed colon cancer receiving curative resection were enrolled. The effect of marital status on 5-year disease-specific survival (DSS) was calculated using Kaplan-Meier method, and was compared by log-rank tests. A Cox regression model was used to find significant independent variables and determine whether marriage had a survival benefit in patients with colon cancer, using stratified analysis. Among these patients, 749 (80.9%) were married, and 176 (19.1%) were unmarried, including 42 (4.5%) never-married, 42 (4.5%) divorced/separated, and 93 (10.1%) widowed. There was no significant difference between the married and unmarried groups in cancer stage or adjuvant treatment. Married patients had better 5-year DSS compared with unmarried patients (69.1% vs 55.9%, P<.001). Uni- and multivariate analyses also indicated that unmarried patients had worse 5-year DSS after adjusting for various confounders (adjusted HR [aHR], 1.66; 95% CI, 1.24-2.22). Further stratified analysis according to demographic variables revealed that unmarried status was a significant negative factor in patients with the following characteristics: age >65 years, female sex, well/moderately differentiated tumor, and advanced tumor-node-metastasis (TNM) stage disease (III-IV). Thus, marriage has a protective effect, and contributes to better survival in patients with surgically treated colon cancer. Additional social support for unmarried colon cancer patients may lead to improve outcomes.
    關聯: Medicine, v.98, n.11, e14856
    Appears in Collections:[藥學系(所)] 期刊論文

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