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| 標題: | The impact of marital status on survival in patients with surgically treated colon cancer |
| 作者: | Ching-Chieh Yang(楊清傑)
Cheng, Li-Chin
Lin, Yu-Wei
Wang, Shih-Chang
Ke, Te-Min
Huang, Chung-I.
Su, Yu-Chieh
Tai, Ming-Hong |
| 貢獻者: | Chi Mei Med Ctr, Dept Radiat Oncol
Natl Sun Yat Sen Univ, Inst Biomed Sci
Chia Nan Univ Pharm & Sci, Dept Pharm
Chi Mei Med Ctr, Div Colorectal Surg
E Da Canc Hosp, Dept Radiat Oncol
Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol
Kaohsiung Med Univ, Coll Med, Fac Med
Natl Sun Yat Sen Univ, Ctr Neurosci |
| 關鍵字: | colon cancer
diagnosis
marital status
survival
treatment |
| 日期: | 2019-03 |
| 上傳時間: | 2020-07-29 13:49:46 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | The aim of this study was to investigate the relationship between marital status and disease outcome in patients with surgically treated colon cancer. Between June 2010 and December 2015, a total of 925 patients with newly diagnosed colon cancer receiving curative resection were enrolled. The effect of marital status on 5-year disease-specific survival (DSS) was calculated using Kaplan-Meier method, and was compared by log-rank tests. A Cox regression model was used to find significant independent variables and determine whether marriage had a survival benefit in patients with colon cancer, using stratified analysis. Among these patients, 749 (80.9%) were married, and 176 (19.1%) were unmarried, including 42 (4.5%) never-married, 42 (4.5%) divorced/separated, and 93 (10.1%) widowed. There was no significant difference between the married and unmarried groups in cancer stage or adjuvant treatment. Married patients had better 5-year DSS compared with unmarried patients (69.1% vs 55.9%, P<.001). Uni- and multivariate analyses also indicated that unmarried patients had worse 5-year DSS after adjusting for various confounders (adjusted HR [aHR], 1.66; 95% CI, 1.24-2.22). Further stratified analysis according to demographic variables revealed that unmarried status was a significant negative factor in patients with the following characteristics: age >65 years, female sex, well/moderately differentiated tumor, and advanced tumor-node-metastasis (TNM) stage disease (III-IV). Thus, marriage has a protective effect, and contributes to better survival in patients with surgically treated colon cancer. Additional social support for unmarried colon cancer patients may lead to improve outcomes. |
| 關聯: | Medicine, v.98, n.11, e14856 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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| 10.1097-MD.0000000000014856.pdf | | 528Kb | Adobe PDF | 306 | 檢視/開啟 | | index.html | | 0Kb | HTML | 1046 | 檢視/開啟 |
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