The impact of marital status on survival in patients with surgically treated colon cancer

doi:10.1097/MD.0000000000014856

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標題:	The impact of marital status on survival in patients with surgically treated colon cancer
作者:	Ching-Chieh Yang(楊清傑) Cheng, Li-Chin Lin, Yu-Wei Wang, Shih-Chang Ke, Te-Min Huang, Chung-I. Su, Yu-Chieh Tai, Ming-Hong
貢獻者:	Chi Mei Med Ctr, Dept Radiat Oncol Natl Sun Yat Sen Univ, Inst Biomed Sci Chia Nan Univ Pharm & Sci, Dept Pharm Chi Mei Med Ctr, Div Colorectal Surg E Da Canc Hosp, Dept Radiat Oncol Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol Kaohsiung Med Univ, Coll Med, Fac Med Natl Sun Yat Sen Univ, Ctr Neurosci
關鍵字:	colon cancer diagnosis marital status survival treatment
日期:	2019-03
上傳時間:	2020-07-29 13:49:46 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	The aim of this study was to investigate the relationship between marital status and disease outcome in patients with surgically treated colon cancer. Between June 2010 and December 2015, a total of 925 patients with newly diagnosed colon cancer receiving curative resection were enrolled. The effect of marital status on 5-year disease-specific survival (DSS) was calculated using Kaplan-Meier method, and was compared by log-rank tests. A Cox regression model was used to find significant independent variables and determine whether marriage had a survival benefit in patients with colon cancer, using stratified analysis. Among these patients, 749 (80.9%) were married, and 176 (19.1%) were unmarried, including 42 (4.5%) never-married, 42 (4.5%) divorced/separated, and 93 (10.1%) widowed. There was no significant difference between the married and unmarried groups in cancer stage or adjuvant treatment. Married patients had better 5-year DSS compared with unmarried patients (69.1% vs 55.9%, P<.001). Uni- and multivariate analyses also indicated that unmarried patients had worse 5-year DSS after adjusting for various confounders (adjusted HR [aHR], 1.66; 95% CI, 1.24-2.22). Further stratified analysis according to demographic variables revealed that unmarried status was a significant negative factor in patients with the following characteristics: age >65 years, female sex, well/moderately differentiated tumor, and advanced tumor-node-metastasis (TNM) stage disease (III-IV). Thus, marriage has a protective effect, and contributes to better survival in patients with surgically treated colon cancer. Additional social support for unmarried colon cancer patients may lead to improve outcomes.
關聯:	Medicine, v.98, n.11, e14856
显示于类别:	[藥學系(所)] 期刊論文

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