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| 標題: | Association of Serum Zinc Concentration with Preservation of Renal Function After Bariatric Surgery: a Retrospective Pilot Study |
| 作者: | Hung, Kuo-Chuan
Wu, Zhi-Fu
Jen-Yin Chen(陳貞吟)
Chen, I-Wen
Ho, Chun-Ning
Lin, Chien-Ming
Chang, Ying-Jen
Hsu, Yu-Rong
Feng, I-Jung
Sun, Cheuk-Kwan
Soong, Tien-Chou |
| 貢獻者: | Chi Mei Med Ctr, Dept Anesthesiol
Triserv Gen Hosp, Dept Anesthesiol
Natl Def Med Ctr, Taipei, Taiwan
Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
E Da Dachang Hosp, Weight Loss & Hlth Management Ctr
Chi Mei Med Ctr, Dept Med Res
E Da Hosp, Dept Emergency Med
I Shou Univ, Sch Med Int Students
I Shou Univ, Coll Med, Dept Occupat Therapy |
| 關鍵字: | Bariatric surgery
Glomerular filtration rate
Renal function
Serum zinc levels |
| 日期: | 2020-03 |
| 上傳時間: | 2020-07-29 13:48:21 (UTC+8) |
| 出版者: | SPRINGER |
| 摘要: | Background Although serum zinc level (Zn) is known to impact renal function in patients with diabetes, their correlation following bariatric surgery remains unknown. This study aimed at assessing the association of Zn with estimated glomerular filtration rate (eGFR) after laparoscopic sleeve gastrectomy (LSG). Methods One hundred and twenty-nine patients in total (mean age, 38.1 +/- 10.8; body mass index, 39.1 +/- 5.1 kg/m(2)) with normal preoperative kidney function undergoing LSG at a single tertiary referral center were reviewed. The primary study endpoint was the relationship between Zn and post-LSG eGFR at 12-month follow-up. The secondary outcomes were the associations of percentage weight loss (%WL) with changes in Zn (oZn) and eGFR (oeGFR). Results The incidence of zinc deficiency was 8.5%, 8.1%, and 29.9% at baseline, post-LSG and one- and 12-month follow-up, respectively. At 12-month follow-up, Zn dropped from 104.1 +/- 19.2 to 85.3 +/- 38.9 mu g/dL (p = 0.001), while eGFR levels decreased from 106.6 +/- 10.3 to 102.1 +/- 19.4 mL/min per 1.73 m(2) (p = 0.025). Zn correlated positively with eGFR at 6-month (r = 0.252, p = 0.037) and 12-month (r = 0.41, p = 0.001) follow-ups. Multiple linear regression analyses including baseline variables of age, sex, BMI, %WL, and diabetes identified Zn and %WL as independent predictors of eGFR at 12-month follow-up. There was no evidence of multicollinearity among these variables. Despite positive association between %WL and oeGFR (r = 0.222, p = 0.031), no correlation was noted between %WL and oZn (r = - 0.129, p = 0.40). Conclusion The results demonstrated a positive relationship between post-LSG serum zinc levels and preservation of renal function among patients with obesity in a surgical setting. Large-scale studies are warranted to support the findings. |
| 關聯: | Obesity Surgery, v.30, n.3, pp.867-874 |
| 顯示於類別: | [高齡福祉養生管理系] 期刊論文
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