Association of Serum Zinc Concentration with Preservation of Renal Function After Bariatric Surgery: a Retrospective Pilot Study

doi:10.1007/s11695-019-04260-1

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標題:	Association of Serum Zinc Concentration with Preservation of Renal Function After Bariatric Surgery: a Retrospective Pilot Study
作者:	Hung, Kuo-Chuan Wu, Zhi-Fu Jen-Yin Chen(陳貞吟) Chen, I-Wen Ho, Chun-Ning Lin, Chien-Ming Chang, Ying-Jen Hsu, Yu-Rong Feng, I-Jung Sun, Cheuk-Kwan Soong, Tien-Chou
貢獻者:	Chi Mei Med Ctr, Dept Anesthesiol Triserv Gen Hosp, Dept Anesthesiol Natl Def Med Ctr, Taipei, Taiwan Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management E Da Dachang Hosp, Weight Loss & Hlth Management Ctr Chi Mei Med Ctr, Dept Med Res E Da Hosp, Dept Emergency Med I Shou Univ, Sch Med Int Students I Shou Univ, Coll Med, Dept Occupat Therapy
關鍵字:	Bariatric surgery Glomerular filtration rate Renal function Serum zinc levels
日期:	2020-03
上傳時間:	2020-07-29 13:48:21 (UTC+8)
出版者:	SPRINGER
摘要:	Background Although serum zinc level (Zn) is known to impact renal function in patients with diabetes, their correlation following bariatric surgery remains unknown. This study aimed at assessing the association of Zn with estimated glomerular filtration rate (eGFR) after laparoscopic sleeve gastrectomy (LSG). Methods One hundred and twenty-nine patients in total (mean age, 38.1 +/- 10.8; body mass index, 39.1 +/- 5.1 kg/m(2)) with normal preoperative kidney function undergoing LSG at a single tertiary referral center were reviewed. The primary study endpoint was the relationship between Zn and post-LSG eGFR at 12-month follow-up. The secondary outcomes were the associations of percentage weight loss (%WL) with changes in Zn (oZn) and eGFR (oeGFR). Results The incidence of zinc deficiency was 8.5%, 8.1%, and 29.9% at baseline, post-LSG and one- and 12-month follow-up, respectively. At 12-month follow-up, Zn dropped from 104.1 +/- 19.2 to 85.3 +/- 38.9 mu g/dL (p = 0.001), while eGFR levels decreased from 106.6 +/- 10.3 to 102.1 +/- 19.4 mL/min per 1.73 m(2) (p = 0.025). Zn correlated positively with eGFR at 6-month (r = 0.252, p = 0.037) and 12-month (r = 0.41, p = 0.001) follow-ups. Multiple linear regression analyses including baseline variables of age, sex, BMI, %WL, and diabetes identified Zn and %WL as independent predictors of eGFR at 12-month follow-up. There was no evidence of multicollinearity among these variables. Despite positive association between %WL and oeGFR (r = 0.222, p = 0.031), no correlation was noted between %WL and oZn (r = - 0.129, p = 0.40). Conclusion The results demonstrated a positive relationship between post-LSG serum zinc levels and preservation of renal function among patients with obesity in a surgical setting. Large-scale studies are warranted to support the findings.
關聯:	Obesity Surgery, v.30, n.3, pp.867-874
显示于类别:	[高齡福祉養生管理系] 期刊論文

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