Statin use and Vital Organ Failure in Patients With Asthma-Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study

doi:10.3389/fphar.2019.00889

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Title:	Statin use and Vital Organ Failure in Patients With Asthma-Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study
Authors:	Yeh, Jun-Jun(葉俊濬) Syue, Shih-Huei Lin, Cheng-Li Hsu, Chung Y. Shae, Zonyin Kao, Chia-Hung
Contributors:	Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Famiy Med Chia Nan Univ Pharm & Sci, Dept Childhood Educ & Nursery China Med Univ, Coll Med Mei Ho Univ, Dept Nursing China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med, Grad Inst Biomed Sci China Med Univ, Coll Med, Sch Med Asia Univ, Dept Comp Sci & Informat Engn China Med Univ Hosp, Dept Nucl Med Asia Univ, Dept Bioinformat & Med Engn
Keywords:	asthma-chronic obstructive pulmonary disease overlap (ACO) hepatic failure renal failure heart failure respiratory failure
Date:	2019-08
Issue Date:	2020-07-29 13:48:07 (UTC+8)
Publisher:	FRONTIERS MEDIA SA
Abstract:	Objective: The effects of statins on the risk of hepatic, renal, respiratory, and heart failure among patients with asthma-chronic obstructive pulmonary disease overlap (ACO) have not been reported. Design: Time-dependent population-based study. Setting: Patient data from 2000 to 2010 were retrieved from the Taiwan National Health Insurance Research Database. Patients: We divided patients with ACO into cohorts of statin use (N = 1,211) and nonuse (N = 7,443). Measurements and Main Results: The cumulative incidence rates of hepatic, renal, respiratory, and heart failure were analyzed through Cox proportional regression analysis with time-dependent variables. After adjustment for multiple confounding factors, including age, sex, comorbidities, and medications [statins, inhaled corticosteroid (ICS), or oral steroid (OS)], the adjusted hazard ratios (aHRs) [95% confidence intervals (CIs)] for hepatic, renal, respiratory, and heart failure were 0.50 (0.40-0.64), 0.49 (0.38-0.64), 0.61 (0.27-2.21), and 0.47 (0.37-0.60), respectively. The aHRs (95% Cls) for statin use with [ICS, OS] for hepatic, renal, and heart failure were [0.36 (0.20-0.66), 0.52 (0.39-0.70)]; [0.82 (0.51-1.34), 0.46 (0.33-0.63)]; and [0.66 (0.40-1.07), 0.48 (0.37-0.64)], respectively. Conclusions: The ACO cohort with statin use exhibited lower risk of hepatic, renal, and heart failure than any other cohort, regardless of age, sex, comorbidities, or ICS or OS use. Regarding the combined use of statins and ICS, the risks of hepatic failure were lower. For the combined use of statins and OS, hepatic, renal, and heart failure were less frequent.
Relation:	Frontiers in Pharmacology, v.10, 889
Appears in Collections:	[Dept. of Childhood Education and Nursery] Periodical Articles

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