Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32508
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17776/20117 (88%)
造访人次 : 10944863      在线人数 : 555
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    標題: Identification of baicalin from Bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signaling-associated pathways
    作者: Kuo, Yu-Ting
    Lin, Chih-Chan
    Hsiao-Tzu Kuo(郭小慈)
    Jui-Hsiang Hung(洪瑞祥)
    Liu, Ching-Hsuan
    Jassey, Alagie
    Yen, Ming-Hong
    Shu-Jing Wu(吳淑靜)
    Lin, Liang-Tzung
    貢獻者: Chi Mei Med Ctr, Dept Med Imaging
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Nutr Hlth
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    Taipei Med Univ, Grad Inst Med Sci, Coll Med
    Dalhousie Univ, Dept Microbiol & Immunol
    Taipei Med Univ, Coll Med, Int PhD Program Med
    Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod
    Taipei Med Univ, Sch Med, Dept Microbiol & Immunol, Coll Med
    關鍵字: Anti-hyperglycemia
    Glucose uptake
    日期: 2019-01
    上傳時間: 2020-07-29 13:47:52 (UTC+8)
    摘要: Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia that can lead to long-term complications including heart diseases, stroke, retinopathy, and renal failure. Treatment strategies include stimulating glucose uptake and controlling blood glucose level. Bofutsushosan (BOF) and Daisaikoto (DAI) are two herb-based kampo medicines that have been demonstrated to improve metabolism-associated disorders including obesity, hyperlipidemia, and nonalcoholic fatty liver. Given their bioactivities against metabolic syndromes, we explored in this study the effect of BOF and DAI extracts on glucose absorption and used them as source to identify phytochemical stimulator of glucose absorption. Glucose uptake and mechanistic studies were evaluated in differentiated C2C12 skeletal muscle cells, and HPLC analysis was used to determine the molecular bioactive constituents. Our results indicated that the ethanolic extracts of BOF and DAI (BOFEE and DAIEE, respectively) enhanced the glucose uptake ratio in the differentiated C2C12 cells, and further analysis identified the flavone baicalin as a major constituent capable of efficiently stimulating glucose absorption. Mechanistic studies revealed that the effect from baicalin involved the activation of IRS-1 and GLUT-4, and implicated the AMPK, PI3K/Akt, and MAPK/ERK signaling cascades. Due to its potency, we suggest that baicalin merit further evaluation as a potential candidate anti-hyperglycemic agent for the treatment and management of T2DM. Copyright (C) 2018, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
    關聯: Journal of Food and Drug Analysis, v.27, n.1, pp.240-248
    显示于类别:[保健營養系(所) ] 期刊論文
    [生物科技系(所)] 期刊論文


    档案 描述 大小格式浏览次数
    10.1016-j.jfda.2018.07.002.pdf880KbAdobe PDF99检视/开启

    在CNU IR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈