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    Title: Identification of baicalin from Bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signaling-associated pathways
    Authors: Kuo, Yu-Ting
    Lin, Chih-Chan
    Hsiao-Tzu Kuo(郭小慈)
    Jui-Hsiang Hung(洪瑞祥)
    Liu, Ching-Hsuan
    Jassey, Alagie
    Yen, Ming-Hong
    Shu-Jing Wu(吳淑靜)
    Lin, Liang-Tzung
    Contributors: Chi Mei Med Ctr, Dept Med Imaging
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Nutr Hlth
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    Taipei Med Univ, Grad Inst Med Sci, Coll Med
    Dalhousie Univ, Dept Microbiol & Immunol
    Taipei Med Univ, Coll Med, Int PhD Program Med
    Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod
    Taipei Med Univ, Sch Med, Dept Microbiol & Immunol, Coll Med
    Keywords: Anti-hyperglycemia
    Glucose uptake
    Date: 2019-01
    Issue Date: 2020-07-29 13:47:52 (UTC+8)
    Abstract: Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia that can lead to long-term complications including heart diseases, stroke, retinopathy, and renal failure. Treatment strategies include stimulating glucose uptake and controlling blood glucose level. Bofutsushosan (BOF) and Daisaikoto (DAI) are two herb-based kampo medicines that have been demonstrated to improve metabolism-associated disorders including obesity, hyperlipidemia, and nonalcoholic fatty liver. Given their bioactivities against metabolic syndromes, we explored in this study the effect of BOF and DAI extracts on glucose absorption and used them as source to identify phytochemical stimulator of glucose absorption. Glucose uptake and mechanistic studies were evaluated in differentiated C2C12 skeletal muscle cells, and HPLC analysis was used to determine the molecular bioactive constituents. Our results indicated that the ethanolic extracts of BOF and DAI (BOFEE and DAIEE, respectively) enhanced the glucose uptake ratio in the differentiated C2C12 cells, and further analysis identified the flavone baicalin as a major constituent capable of efficiently stimulating glucose absorption. Mechanistic studies revealed that the effect from baicalin involved the activation of IRS-1 and GLUT-4, and implicated the AMPK, PI3K/Akt, and MAPK/ERK signaling cascades. Due to its potency, we suggest that baicalin merit further evaluation as a potential candidate anti-hyperglycemic agent for the treatment and management of T2DM. Copyright (C) 2018, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
    Relation: Journal of Food and Drug Analysis, v.27, n.1, pp.240-248
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles
    [Dept. of Biotechnology (including master's program)] Periodical Articles

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