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| 標題: | Colistin-sparing regimens against Klebsiella pneumoniae carbapenemase-producing K-pneumoniae isolates: Combination of tigecycline or doxycycline and gentamicin or amikacin |
| 作者: | Hung-Jen Tang(湯宏仁)
Lai, Chih-Cheng
Chen, Chi-Chung
Zhang, Chun-Cheng
Weng, Tzu-Chieh
Chiu, Yu-Hsin
Toh, Han-Siong
Chiang, Shyh-Ren
Yu, Wen-Liang
Ko, Wen-Chien
Chuang, Yin-Ching |
| 貢獻者: | Chi Mei Med Ctr, Dept Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chi Mei Med Ctr, Dept Intens Care Med
Chi Mei Med Ctr, Dept Med Res, 901 Chung Hwa Rd
Natl Cheng Kung Univ, Med Coll & Hosp, Inst Biotechnol
Natl Cheng Kung Univ, Dept Med, Med Coll & Hosp |
| 關鍵字: | aminoglycoside
doxycycline
KPC
synergism
tigecycline |
| 日期: | 2019-04 |
| 上傳時間: | 2020-07-29 13:47:38 (UTC+8) |
| 出版者: | ELSEVIER TAIWAN |
| 摘要: | Background/Purpose: In vitro studies of the combination of an aminoglycoside with tigecycline or doxycycline against Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates are rarely published. The goal of this study was to evaluate the antibacterial activity of the combination regimens. Methods: Thirteen genetically different KPC-producing K. pneumoniae isolates were randomly selected. Drug concentrations of amikacin, gentamicin, tigecycline, and doxycycline were adjusted to 1-, 1/2-, and 1/4-fold of respective minimum inhibitory concentrations (MICs). Each drug alone or the combinations of amikacin or gentamicin with tigecycline or doxycycline were tested by combination studies. Results: Treatment with the 1x MIC concentration in combinations of amikacin or gentamicin and tigecycline or doxycycline for 24 hours resulted in bactericidal activity of 84-100% in the isolates. Treatment with 1/2x MIC combinations resulted in synergism of 69-100% in the isolates. Notably, doxycycline plus gentamicin or amikacin was synergistic for all tested isolates. However, bactericidal or synergistic effect was barely evident following 1/4x MIC combinations. There was no antagonism in any of the combination regimens. Conclusion: Enhanced activity was noted following treatment with doxycycline combined with gentamicin or amikacin against KPC-producing K. pneumoniae isolates, warranting further in vitro and animal investigations before clinical application. Copyright (C) 2016, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. |
| 關聯: | Journal of Microbiology Immunology and Infection, v.52, n.2, pp.273-281 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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