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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32503


    標題: Colistin-sparing regimens against Klebsiella pneumoniae carbapenemase-producing K-pneumoniae isolates: Combination of tigecycline or doxycycline and gentamicin or amikacin
    作者: Hung-Jen Tang(湯宏仁)
    Lai, Chih-Cheng
    Chen, Chi-Chung
    Zhang, Chun-Cheng
    Weng, Tzu-Chieh
    Chiu, Yu-Hsin
    Toh, Han-Siong
    Chiang, Shyh-Ren
    Yu, Wen-Liang
    Ko, Wen-Chien
    Chuang, Yin-Ching
    貢獻者: Chi Mei Med Ctr, Dept Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Med Res, 901 Chung Hwa Rd
    Natl Cheng Kung Univ, Med Coll & Hosp, Inst Biotechnol
    Natl Cheng Kung Univ, Dept Med, Med Coll & Hosp
    關鍵字: aminoglycoside
    doxycycline
    KPC
    synergism
    tigecycline
    日期: 2019-04
    上傳時間: 2020-07-29 13:47:38 (UTC+8)
    出版者: ELSEVIER TAIWAN
    摘要: Background/Purpose: In vitro studies of the combination of an aminoglycoside with tigecycline or doxycycline against Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates are rarely published. The goal of this study was to evaluate the antibacterial activity of the combination regimens. Methods: Thirteen genetically different KPC-producing K. pneumoniae isolates were randomly selected. Drug concentrations of amikacin, gentamicin, tigecycline, and doxycycline were adjusted to 1-, 1/2-, and 1/4-fold of respective minimum inhibitory concentrations (MICs). Each drug alone or the combinations of amikacin or gentamicin with tigecycline or doxycycline were tested by combination studies. Results: Treatment with the 1x MIC concentration in combinations of amikacin or gentamicin and tigecycline or doxycycline for 24 hours resulted in bactericidal activity of 84-100% in the isolates. Treatment with 1/2x MIC combinations resulted in synergism of 69-100% in the isolates. Notably, doxycycline plus gentamicin or amikacin was synergistic for all tested isolates. However, bactericidal or synergistic effect was barely evident following 1/4x MIC combinations. There was no antagonism in any of the combination regimens. Conclusion: Enhanced activity was noted following treatment with doxycycline combined with gentamicin or amikacin against KPC-producing K. pneumoniae isolates, warranting further in vitro and animal investigations before clinical application. Copyright (C) 2016, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
    關聯: Journal of Microbiology Immunology and Infection, v.52, n.2, pp.273-281
    Appears in Collections:[保健營養系(所) ] 期刊論文

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