Colistin-sparing regimens against Klebsiella pneumoniae carbapenemase-producing K-pneumoniae isolates: Combination of tigecycline or doxycycline and gentamicin or amikacin

doi:10.1016/j.jmii.2016.03.003

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/32503

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Title:	Colistin-sparing regimens against Klebsiella pneumoniae carbapenemase-producing K-pneumoniae isolates: Combination of tigecycline or doxycycline and gentamicin or amikacin
Authors:	Hung-Jen Tang(湯宏仁) Lai, Chih-Cheng Chen, Chi-Chung Zhang, Chun-Cheng Weng, Tzu-Chieh Chiu, Yu-Hsin Toh, Han-Siong Chiang, Shyh-Ren Yu, Wen-Liang Ko, Wen-Chien Chuang, Yin-Ching
Contributors:	Chi Mei Med Ctr, Dept Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Intens Care Med Chi Mei Med Ctr, Dept Med Res, 901 Chung Hwa Rd Natl Cheng Kung Univ, Med Coll & Hosp, Inst Biotechnol Natl Cheng Kung Univ, Dept Med, Med Coll & Hosp
Keywords:	aminoglycoside doxycycline KPC synergism tigecycline
Date:	2019-04
Issue Date:	2020-07-29 13:47:38 (UTC+8)
Publisher:	ELSEVIER TAIWAN
Abstract:	Background/Purpose: In vitro studies of the combination of an aminoglycoside with tigecycline or doxycycline against Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates are rarely published. The goal of this study was to evaluate the antibacterial activity of the combination regimens. Methods: Thirteen genetically different KPC-producing K. pneumoniae isolates were randomly selected. Drug concentrations of amikacin, gentamicin, tigecycline, and doxycycline were adjusted to 1-, 1/2-, and 1/4-fold of respective minimum inhibitory concentrations (MICs). Each drug alone or the combinations of amikacin or gentamicin with tigecycline or doxycycline were tested by combination studies. Results: Treatment with the 1x MIC concentration in combinations of amikacin or gentamicin and tigecycline or doxycycline for 24 hours resulted in bactericidal activity of 84-100% in the isolates. Treatment with 1/2x MIC combinations resulted in synergism of 69-100% in the isolates. Notably, doxycycline plus gentamicin or amikacin was synergistic for all tested isolates. However, bactericidal or synergistic effect was barely evident following 1/4x MIC combinations. There was no antagonism in any of the combination regimens. Conclusion: Enhanced activity was noted following treatment with doxycycline combined with gentamicin or amikacin against KPC-producing K. pneumoniae isolates, warranting further in vitro and animal investigations before clinical application. Copyright (C) 2016, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
Relation:	Journal of Microbiology Immunology and Infection, v.52, n.2, pp.273-281
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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