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| 標題: | Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer |
| 作者: | Wu, Pei-Yi
Lin, Yueh-Chien
Huang, Yuan-Li
Chen, Wei-Min
Chen, Chien-Chin
Lee, Hsinyu |
| 貢獻者: | Acad Sinica, Inst Cellular & Organism Biol
Natl Taiwan Univ, Dept Life Sci
Asia Univ, Dept Biotechnol
China Med Univ, China Med Univ Hosp, Dept Med Res
Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Natl Taiwan Univ, Dept Elect Engn
Natl Taiwan Univ, Inst Biomed Elect & Bioinformat
Natl Taiwan Univ, Ctr Biotechnol |
| 關鍵字: | LPA
LPA receptor
prostate cancer
VEGF-C
lymphangiogenesis |
| 日期: | 2018-11 |
| 上傳時間: | 2019-12-16 09:35:42 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph nodes via lymphatic vessels. Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis. Many of the underlying molecular mechanisms of the LPA-VEGF-C axis have been described, revealing potential biomarkers and therapeutic targets that may aid in the diagnosis and treatment of advanced PCa. Herein, we review the literature that illustrates a functional role for LPA signaling in PCa progression. These discoveries may be especially applicable to anti-lymphangiogenic strategies for the prevention and therapy of metastatic PCa. |
| 關聯: | Molecular Carcinogenesis, v.10, n.11, 413 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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