Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer

doi:10.3390/cancers10110413

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/32324

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32324

Title:	Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
Authors:	Wu, Pei-Yi Lin, Yueh-Chien Huang, Yuan-Li Chen, Wei-Min Chen, Chien-Chin Lee, Hsinyu
Contributors:	Acad Sinica, Inst Cellular & Organism Biol Natl Taiwan Univ, Dept Life Sci Asia Univ, Dept Biotechnol China Med Univ, China Med Univ Hosp, Dept Med Res Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Natl Taiwan Univ, Dept Elect Engn Natl Taiwan Univ, Inst Biomed Elect & Bioinformat Natl Taiwan Univ, Ctr Biotechnol
Keywords:	LPA LPA receptor prostate cancer VEGF-C lymphangiogenesis
Date:	2018-11
Issue Date:	2019-12-16 09:35:42 (UTC+8)
Publisher:	MDPI
Abstract:	Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph nodes via lymphatic vessels. Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis. Many of the underlying molecular mechanisms of the LPA-VEGF-C axis have been described, revealing potential biomarkers and therapeutic targets that may aid in the diagnosis and treatment of advanced PCa. Herein, we review the literature that illustrates a functional role for LPA signaling in PCa progression. These discoveries may be especially applicable to anti-lymphangiogenic strategies for the prevention and therapy of metastatic PCa.
Relation:	Molecular Carcinogenesis, v.10, n.11, 413
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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