Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer

doi:10.3390/cancers10110413

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/32324

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题名:	Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
作者:	Wu, Pei-Yi Lin, Yueh-Chien Huang, Yuan-Li Chen, Wei-Min Chen, Chien-Chin Lee, Hsinyu
贡献者:	Acad Sinica, Inst Cellular & Organism Biol Natl Taiwan Univ, Dept Life Sci Asia Univ, Dept Biotechnol China Med Univ, China Med Univ Hosp, Dept Med Res Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Natl Taiwan Univ, Dept Elect Engn Natl Taiwan Univ, Inst Biomed Elect & Bioinformat Natl Taiwan Univ, Ctr Biotechnol
关键词:	LPA LPA receptor prostate cancer VEGF-C lymphangiogenesis
日期:	2018-11
上传时间:	2019-12-16 09:35:42 (UTC+8)
出版者:	MDPI
摘要:	Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph nodes via lymphatic vessels. Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis. Many of the underlying molecular mechanisms of the LPA-VEGF-C axis have been described, revealing potential biomarkers and therapeutic targets that may aid in the diagnosis and treatment of advanced PCa. Herein, we review the literature that illustrates a functional role for LPA signaling in PCa progression. These discoveries may be especially applicable to anti-lymphangiogenic strategies for the prevention and therapy of metastatic PCa.
關聯:	Molecular Carcinogenesis, v.10, n.11, 413
显示于类别:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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