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| 標題: | Regulatory Efficacy of Brown Seaweed Lessonia nigrescens Extract on the Gene Expression Profile and Intestinal Microflora in Type 2 Diabetic Mice |
| 作者: | Zhao, Chao
Yang, Chengfeng
Chen, Mingjun
Lv, Xucong
Liu, Bin
Yi, Lunzhao
Cornara, Laura
Wei, Ming-Chi
Yang, Yu-Chiao
Tundis, Rosa
Xiao, Jianbo |
| 貢獻者: | Fujian Agr & Forestry Univ, Coll Food Sci
Univ Calif Davis, Dept Chem
Quanzhou Normal Univ, Fujian Prov Key Lab Dev Bioact Mat Marine Algae
Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst
Univ Genoa, Dipartimento Sci Terra Ambiente & Vita, Genoa
Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat
Kaohsiung Med Univ, Dept & Grad Inst Pharmacol
Univ Calabria, Dept Pharm Hlth & Nutr Sci, Arcavacata Di Rende
Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Ave Univ |
| 關鍵字: | anti-diabetic activity
high-throughput 16S rRNA gene sequencing
intestinal microflora
Lessonia nigrescens
signaling pathway |
| 日期: | 2018-02 |
| 上傳時間: | 2019-11-15 15:48:58 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Scope: In this study, the antidiabetic activity of Lessonia nigrescens ethanolic extract (LNE) is investigated in streptozotocin (SZT)-induced type 2 diabetic mice fed with a high-sucrose/high-fat diet. Methods and results: Ultra high performance liquid chromatography coupled with photo-DAD and electospray ionization-mass spectrometry (ESI-MS) is employed to analyze the major compounds in LNE. The components of the intestinal microflora in type 2 diabetic mice are analyzed by high-throughput next-generation 16S rRNA gene sequencing. Fasting blood glucose levels in diabetic mice are significantly decreased after LNE administration. The histology reveals that LNE could protect the cellular architecture of liver and kidney. LNE treatment significantly increases Bacteroidetes and decreases Firmicutes populations in intestinal microflora. Specifically, It could selectively enrich the amounts of beneficial bacteria, Barnesiella, as well as reduce the abundances of Clostridium and Alistipes. The increased gene and protein expression levels of phosphatidylinositol 3-kinase (PI3K) in the liver are observed in LNE treatment groups, while the expressions of c-Jun N-terminal kinase (JNK) are significantly downregulated. Conclusion: The above findings suggest that LNE could be considered as a functional food for reducing blood glucose and regulating intestinal microflora. |
| link: | http://dx.doi.org/10.1002/mnfr.201700730 |
| 關聯: | Cancer Medicine, v.62, n.4, 1700730 |
| 顯示於類別: | [應用空間資訊系(所)] 期刊論文
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