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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32306

    標題: Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway
    作者: Uen, Yih-Huei
    Fang, Chia-Lang
    Lin, Chih-Chan
    Hseu, You-Cheng
    Hung, Shih-Ting
    Sun, Ding-Ping
    Lin, Kai-Yuan
    貢獻者: Asia Univ Hosp, Dept Surg
    Asia Univ, Dept Biotechnol
    Tainan Municipal An Nan Hosp, Dept Surg
    Taipei Med Univ, Sch Med, Dept Pathol, Coll Med
    Taipei Med Univ, Wan Fang Hosp, Dept Pathol
    Chi Mei Med Ctr, Dept Med Res
    China Med Univ, Dept Cosmeceut
    Asia Univ, Dept Hlth & Nutr Biotechnol
    Chi Mei Med Ctr, Dept Surg
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    關鍵字: CERS6
    gastric cancer
    日期: 2018-12
    上傳時間: 2019-11-15 15:48:56 (UTC+8)
    出版者: WILEY
    摘要: Although gastric cancer (GC) is one of the most common cancers, knowledge of its development, and carcinogenesis is limited. The present study explored the involvement of ceramide synthase 6 (CERS6) in GC carcinogenesis and prognosis. RT-PCR, immunoblotting, and immunohistochemistry were used to examine the expression of CERS6. Transfection and small hairpin RNA technology were used to investigate the effect of CERS6 manipulation on cell proliferation and spread as well as the underlying mechanism. Moreover, xenograft proliferation was employed to explore the influence of CERS6 on tumor growth in animals. It was found that overexpression of CERS6 was significantly correlated with several clinicopathologic parameters and poor disease-free survival. The overexpression and silencing of CERS6 in GC cells facilitated and suppressed cell proliferation and spread as well as xenograft proliferation, respectively. Mechanistic studies further revealed that CERS6 influenced cell proliferation and spread by regulating cell cycle control and metastasis-related protein through the SOCS2/JAK2/STAT3 signaling pathway. Collectively, this study suggests that CERS6 overexpression could be a useful biomarker for predicting the outcomes of GC patients and that CERS6 targeting represents a potential modality for treating GC.
    link: http://dx.doi.org/10.1002/mc.22888
    關聯: Molecular Nutrition & Food Research, v.57, n.12, pp.1675-1689
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文
    [生物科技系(所)] 期刊論文

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