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| 標題: | Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway |
| 作者: | Uen, Yih-Huei
Fang, Chia-Lang
Lin, Chih-Chan
Hseu, You-Cheng
Hung, Shih-Ting
Sun, Ding-Ping
Lin, Kai-Yuan |
| 貢獻者: | Asia Univ Hosp, Dept Surg
Asia Univ, Dept Biotechnol
Tainan Municipal An Nan Hosp, Dept Surg
Taipei Med Univ, Sch Med, Dept Pathol, Coll Med
Taipei Med Univ, Wan Fang Hosp, Dept Pathol
Chi Mei Med Ctr, Dept Med Res
China Med Univ, Dept Cosmeceut
Asia Univ, Dept Hlth & Nutr Biotechnol
Chi Mei Med Ctr, Dept Surg
Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
Chia Nan Univ Pharm & Sci, Dept Biotechnol |
| 關鍵字: | CERS6
gastric cancer
immunohistochemistry
prognosis
SOCS2 |
| 日期: | 2018-12 |
| 上傳時間: | 2019-11-15 15:48:56 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Although gastric cancer (GC) is one of the most common cancers, knowledge of its development, and carcinogenesis is limited. The present study explored the involvement of ceramide synthase 6 (CERS6) in GC carcinogenesis and prognosis. RT-PCR, immunoblotting, and immunohistochemistry were used to examine the expression of CERS6. Transfection and small hairpin RNA technology were used to investigate the effect of CERS6 manipulation on cell proliferation and spread as well as the underlying mechanism. Moreover, xenograft proliferation was employed to explore the influence of CERS6 on tumor growth in animals. It was found that overexpression of CERS6 was significantly correlated with several clinicopathologic parameters and poor disease-free survival. The overexpression and silencing of CERS6 in GC cells facilitated and suppressed cell proliferation and spread as well as xenograft proliferation, respectively. Mechanistic studies further revealed that CERS6 influenced cell proliferation and spread by regulating cell cycle control and metastasis-related protein through the SOCS2/JAK2/STAT3 signaling pathway. Collectively, this study suggests that CERS6 overexpression could be a useful biomarker for predicting the outcomes of GC patients and that CERS6 targeting represents a potential modality for treating GC. |
| link: | http://dx.doi.org/10.1002/mc.22888 |
| 關聯: | Molecular Nutrition & Food Research, v.57, n.12, pp.1675-1689 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
[生物科技系(所)] 期刊論文
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