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請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/32305
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| 標題: | Angiotensin 1-7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway |
| 作者: | Lu, Yen-Yu
Wu, Wen-Shiann
Lin, Yung-Kuo
Cheng, Chen-Chuan
Chen, Yao-Chang
Chen, Shih-Ann
Chen, Yi-Jen |
| 關鍵字: | angiotensin-(1-7)
calcium homoeostasis
electrophysiology
pulmonary vein |
| 日期: | 2018-01 |
| 上傳時間: | 2019-11-15 15:48:52 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia, and pulmonary veins (PVs) play a critical role in triggering AF. Angiotensin (Ang)-(1-7) regulates calcium (Ca2+) homoeostasis and also plays a critical role in cardiovascular pathophysiology. However, the role of Ang-(1-7) in PV arrhythmogenesis remains unclear. Materials and methodsConventional microelectrodes, whole-cell patch-clamp and the fluo-3 fluorimetric ratio technique were used to record ionic currents and intracellular Ca2+ in isolated rabbit PV preparations and in single isolated PV cardiomyocytes, before and after administration of Ang-(1-7). ResultsAng (1-7) concentration dependently (0.1, 1, 10 and 100 nmol/L) decreased PV spontaneous electrical activity. Ang-(1-7) (100 nmol/L) decreased the late sodium (Na+), L-type Ca2+ and Na+-Ca2+ exchanger currents, but did not affect the voltage-dependent Na+ current in PV cardiomyocytes. In addition, Ang-(1-7) decreased intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. A779 (a Mas receptor blocker, 3 mol/L), L-NAME (a NO synthesis inhibitor, 100 mol/L) or wortmannin (a specific PI3K inhibitor, 10 nmol/L) attenuated the effects of Ang-(1-7) (100 nmol/L) on PV spontaneous electric activity. ConclusionAng-(1-7) regulates PV electrophysiological characteristics and Ca2+ homoeostasis via Mas/PI3K/eNOS signalling pathway. |
| link: | https://doi.org/10.1111/eci.12854 |
| 關聯: | Molecular Carcinogenesis, v.48, n.1, pp.UNSP e12854 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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