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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32303

    標題: Patterns of failure after postoperative intensity-modulated radiotherapy for locally advanced buccal cancer: Initial masticator space involvement is the key factor of recurrence
    作者: Lin, Yu-Wei
    Chen, Ya-Fang
    Yang, Ching-Chieh
    Ho, Chung-Han
    Wu, Tai-Ching
    Yen, Ching-Yu
    Lin, Li-Ching
    Lee, Steve P.
    Lee, Ching-Chih
    Tai, Ming-Hong
    貢獻者: Chi Mei Med Ctr, Dept Radiat Oncol
    Natl Sun Yat Sen Univ, Inst Biomed Sci
    Natl Taiwan Univ Hosp, Dept Med Imaging
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Chi Mei Hosp, Dept Radiol
    Chi Mei Med Ctr, Dept Oral & Maxillofacial Surg
    Univ Calif Los Angeles, Dept Radiat Oncol
    Kaohsiung Vet Gen Hosp, Dept Otolaryngol Head & Neck Surg
    Natl Def Med Ctr, Sch Med
    Triserv Gen Hosp, Dept Otolaryngol Head & Neck Surg
    Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm
    Natl Yang Ming Univ, Sch Med
    關鍵字: adjuvant radiotherapy
    buccal cancer
    oral cavity cancer
    patterns of failure
    postoperative intensity-modulated radiotherapy (IMRT)
    日期: 2018-12
    上傳時間: 2019-11-15 15:48:48 (UTC+8)
    出版者: WILEY
    摘要: Background The purpose of this study was to determine failure patterns and clinicopathologic prognostic factors in patients with locally advanced buccal cancer after postoperative intensity-modulated radiotherapy (IMRT). Methods Eighty-two patients with locally advanced (American Joint Committee on Cancer [AJCC] stage III/IV) buccal cancer who underwent surgery followed by postoperative IMRT between January 2007 and October 2012 were retrospectively analyzed. Results Eighteen patients had local recurrences as the first recurrent site and 11 had supramandibular notch recurrences; the majority of recurrences were classified as marginal failures. The median time from the first local or regional recurrence to death was 5.9 months. In multivariate analyses of survivals, the initial masticator space involvement was the most important prognostic factor. Masticator space involvement, N classification, and maxillectomy were the significant prognostic predictors for supramandibular notch recurrences. Conclusion Postoperative IMRT for buccal cancer should not include the surgical beds alone, rather, it should be based on the potential patterns of spread.
    link: http://dx.doi.org/10.1002/hed.25355
    關聯: Journal of Oral Pathology & Medicine, v.40, n.12, pp.2621-2632
    Appears in Collections:[醫務管理系(所)] 期刊論文

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