Patterns of failure after postoperative intensity-modulated radiotherapy for locally advanced buccal cancer: Initial masticator space involvement is the key factor of recurrence

doi:10.1002/hed.25355

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Title:	Patterns of failure after postoperative intensity-modulated radiotherapy for locally advanced buccal cancer: Initial masticator space involvement is the key factor of recurrence
Authors:	Lin, Yu-Wei Chen, Ya-Fang Yang, Ching-Chieh Ho, Chung-Han Wu, Tai-Ching Yen, Ching-Yu Lin, Li-Ching Lee, Steve P. Lee, Ching-Chih Tai, Ming-Hong
Contributors:	Chi Mei Med Ctr, Dept Radiat Oncol Natl Sun Yat Sen Univ, Inst Biomed Sci Natl Taiwan Univ Hosp, Dept Med Imaging Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Chi Mei Hosp, Dept Radiol Chi Mei Med Ctr, Dept Oral & Maxillofacial Surg Univ Calif Los Angeles, Dept Radiat Oncol Kaohsiung Vet Gen Hosp, Dept Otolaryngol Head & Neck Surg Natl Def Med Ctr, Sch Med Triserv Gen Hosp, Dept Otolaryngol Head & Neck Surg Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm Natl Yang Ming Univ, Sch Med
Keywords:	adjuvant radiotherapy buccal cancer oral cavity cancer patterns of failure postoperative intensity-modulated radiotherapy (IMRT)
Date:	2018-12
Issue Date:	2019-11-15 15:48:48 (UTC+8)
Publisher:	WILEY
Abstract:	Background The purpose of this study was to determine failure patterns and clinicopathologic prognostic factors in patients with locally advanced buccal cancer after postoperative intensity-modulated radiotherapy (IMRT). Methods Eighty-two patients with locally advanced (American Joint Committee on Cancer [AJCC] stage III/IV) buccal cancer who underwent surgery followed by postoperative IMRT between January 2007 and October 2012 were retrospectively analyzed. Results Eighteen patients had local recurrences as the first recurrent site and 11 had supramandibular notch recurrences; the majority of recurrences were classified as marginal failures. The median time from the first local or regional recurrence to death was 5.9 months. In multivariate analyses of survivals, the initial masticator space involvement was the most important prognostic factor. Masticator space involvement, N classification, and maxillectomy were the significant prognostic predictors for supramandibular notch recurrences. Conclusion Postoperative IMRT for buccal cancer should not include the surgical beds alone, rather, it should be based on the potential patterns of spread.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1002/hed.25355
Relation:	Journal of Oral Pathology & Medicine, v.40, n.12, pp.2621-2632
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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