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| 標題: | Manufacture and characterization of anti-inflammatory liposomes from jumbo flying squid (Dosidicus gigas) skin phospholipid extraction |
| 作者: | Kao, Yi-Feng
Wu, Yi-Hsieng Samuel
Chou, Chung-Hsi
Fu, Shih-Guei
Liu, Cheng-Wei
Chai, Huey-Jine
Chen, Yi-Chen |
| 貢獻者: | Council Agr, Seafood Technol Div, Fisheries Res Inst
Natl Taiwan Univ, Dept Anim Sci & Technol
Natl Taiwan Univ, Sch Vet Med
Natl Taiwan Univ, Zoonoses Res Ctr
Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
MingDao Univ, Dept Post Modern Agr |
| 關鍵字: | Apoptotic Cells
Phosphatidylserine Liposomes
Macrophages
Involvement
Activation
Beta
Rats
Inflammation
Modulation
Clearance |
| 日期: | 2018-07-01 |
| 上傳時間: | 2019-11-15 15:47:39 (UTC+8) |
| 出版者: | ROYAL SOC CHEMISTRY |
| 摘要: | The anti-inflammation properties of marine phospholipids enriched with n-3 fatty acids contribute to anti-inflammatory and inflammation-resolving mediators. Functional squid-skin (SQ) liposomes were manufactured from squid-skin phospholipids, and their anti-inflammatory effects were investigated. SQ liposomes included phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), phosphatidylcholine (PC), and lysophosphatidylcholine (Lyso-PC), and had an approximate diameter of 100 mm. When RAW264.7 cells were treated with the SQ liposome, no (p > 0.05) cytotoxicity was observed below a concentration of 7.5 mg mL(-1). An SQ-liposome pretreatment of lipopolysaccharide (LPS)-induced RAW 264.7 cells showed decreased (p < 0.05) prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1beta (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-). The engulfment of SQ liposomes by the RAW264.7 cells resulted in lower (p < 0.05) LPS-induced intracellular levels of reactive oxygen species. Furthermore, an SQ-liposome administration ameliorated (p < 0.05) carrageenan-induced paw edema in mice. SQ liposomes may act via apoptotic mimicry to elicit the resolution of inflammation and prevent chronic inflammation-related diseases. |
| link: | http://dx.doi.org/10.1039/c8fo00767e |
| 關聯: | Integrative Cancer Therapies, v.9, n.7, pp.3986-3996 |
| 顯示於類別: | [生活保健科技系] 期刊論文
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