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| 標題: | Changing seroprevalence of hepatitis C virus infection among HIV-positive patients in Taiwan |
| 作者: | Li, Chia-Wen
Yang, Chia-Jui
Sun, Hsin-Yun
Tsai, Mao-Song
Lin, Shih-Ping
Lin, Te-Yu
Cheng, Chien-Yu
Lee, Yi-Chien
Huang, Yu-Shan
Liu, Chun-Eng
Lee, Yuan-Ti
Tang, Hung-Jen
Wang, Ning-Chi
Cheng, Shu-Hsing
Ko, Wen-Chien
Hung, Chien-Ching |
| 貢獻者: | Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Internal Med
Far Eastern Mem Hosp, Dept Internal Med
Natl Yang Ming Univ, Sch Med
Natl Taiwan Univ Hosp, Dept Internal Med
Natl Taiwan Univ
Catholic Fu Jen Med Coll, Dept Internal Med
Taichung Vet Gen Hosp, Dept Internal Med
Tri Serv Gen Hosp, Dept Internal Med
Natl Def Med Ctr
Taoyuan Gen Hosp, Minist Hlth & Welf, Dept Infect Dis
Natl Yang Ming Univ, Sch Publ Hlth
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med
Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
Changhua Christian Hosp, Dept Internal Med
Chung Shan Med Univ, Sch Med
Chung Shan Med Univ Hosp, Dept Internal Med
Chi Mei Med Ctr, Dept Internal Med |
| 關鍵字: | B-Virus
Risk-Factors
Viral-Hepatitis
Epidemiology
Men
Sex
Coinfection
Prevalence
Era |
| 日期: | 2018-03-16 |
| 上傳時間: | 2019-11-15 15:47:28 (UTC+8) |
| 出版者: | PUBLIC LIBRARY SCIENCE |
| 摘要: | Objective The study aimed to describe the evolution of the seroprevalence of hepatitis C virus (HCV) among human immunodeficiency virus (HIV)-positive patients included in two cohorts in Taiwan. Methods We retrospectively collected the information on demographic and clinical characteristics of 4,025 and 3,856 HIV-positive Taiwanese, who were aged 18 years or older at designated hospitals around Taiwan in 2004 +/- 2007, when an outbreak of HIV infection was occurring, and 2012 +/- 2016, when the outbreak was controlled with the implementation of harm reduction program, respectively. Comparisons of HCV seropositivity were made among different age and risk groups for HIV transmission between these two cohorts. Results The overall HCV seroprevalence of the 2004-2007 cohort and 2012-2016 cohort was 43.4% (1,288/2,974) and 18.6% (707/3,793), respectively (P<0.001). The HCV seroprevalence among injecting drug users (IDUs), though decreasing, was constantly high across the two cohorts, 96.4% and 94.0% (P = 0.02), respectively, and all age groups. In contrast, the corresponding figures among men who have sex with men (MSM) and heterosexuals in the two cohorts were 5.9% vs. 3.5% (P = 0.002) and 9.4% vs. 10.9% (P = 0.59), respectively. Among sexually transmitted HIV-positive patients, HCV seropositivity was significantly correlated with age (adjusted odds ratio [aOR], per 1-year increase, 1.03; 95% confidence interval [CI], 1.02-1.05) and a rapid plasma reagin (RPR) titer >= 1: 8 (aOR, 1.58; 95% CI, 1.03-2.43) in a multivariate analysis including age, gender, route for HIV transmission, baseline CD4 count and plasma HIV RNA load, the presence of hepatitis B surface antigen, and an RPR titer >= 1: 8. Compared with heterosexuals, the aOR for HCV seropositivity among MSM was 0.47 (95% CI, 0.31-0.72). Conclusions HCV seroprevalence among HIV-positive patients in Taiwan decreased with time, probably related to the inclusion of younger adults and more non-IDUs, and remained high among IDUs. HCV seropositivity was associated with age and an RPR titer >= 1: 8 among patients who acquired HIV through sexual contact. |
| link: | http://dx.doi.org/10.1371/journal.pone.0194149 |
| 關聯: | Plos One, v.13, n.3, e0194149 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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