Changing seroprevalence of hepatitis C virus infection among HIV-positive patients in Taiwan

doi:10.1371/journal.pone.0194149

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Title:	Changing seroprevalence of hepatitis C virus infection among HIV-positive patients in Taiwan
Authors:	Li, Chia-Wen Yang, Chia-Jui Sun, Hsin-Yun Tsai, Mao-Song Lin, Shih-Ping Lin, Te-Yu Cheng, Chien-Yu Lee, Yi-Chien Huang, Yu-Shan Liu, Chun-Eng Lee, Yuan-Ti Tang, Hung-Jen Wang, Ning-Chi Cheng, Shu-Hsing Ko, Wen-Chien Hung, Chien-Ching
Contributors:	Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Internal Med Far Eastern Mem Hosp, Dept Internal Med Natl Yang Ming Univ, Sch Med Natl Taiwan Univ Hosp, Dept Internal Med Natl Taiwan Univ Catholic Fu Jen Med Coll, Dept Internal Med Taichung Vet Gen Hosp, Dept Internal Med Tri Serv Gen Hosp, Dept Internal Med Natl Def Med Ctr Taoyuan Gen Hosp, Minist Hlth & Welf, Dept Infect Dis Natl Yang Ming Univ, Sch Publ Hlth Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch Changhua Christian Hosp, Dept Internal Med Chung Shan Med Univ, Sch Med Chung Shan Med Univ Hosp, Dept Internal Med Chi Mei Med Ctr, Dept Internal Med
Keywords:	B-Virus Risk-Factors Viral-Hepatitis Epidemiology Men Sex Coinfection Prevalence Era
Date:	2018-03-16
Issue Date:	2019-11-15 15:47:28 (UTC+8)
Publisher:	PUBLIC LIBRARY SCIENCE
Abstract:	Objective The study aimed to describe the evolution of the seroprevalence of hepatitis C virus (HCV) among human immunodeficiency virus (HIV)-positive patients included in two cohorts in Taiwan. Methods We retrospectively collected the information on demographic and clinical characteristics of 4,025 and 3,856 HIV-positive Taiwanese, who were aged 18 years or older at designated hospitals around Taiwan in 2004 +/- 2007, when an outbreak of HIV infection was occurring, and 2012 +/- 2016, when the outbreak was controlled with the implementation of harm reduction program, respectively. Comparisons of HCV seropositivity were made among different age and risk groups for HIV transmission between these two cohorts. Results The overall HCV seroprevalence of the 2004-2007 cohort and 2012-2016 cohort was 43.4% (1,288/2,974) and 18.6% (707/3,793), respectively (P<0.001). The HCV seroprevalence among injecting drug users (IDUs), though decreasing, was constantly high across the two cohorts, 96.4% and 94.0% (P = 0.02), respectively, and all age groups. In contrast, the corresponding figures among men who have sex with men (MSM) and heterosexuals in the two cohorts were 5.9% vs. 3.5% (P = 0.002) and 9.4% vs. 10.9% (P = 0.59), respectively. Among sexually transmitted HIV-positive patients, HCV seropositivity was significantly correlated with age (adjusted odds ratio [aOR], per 1-year increase, 1.03; 95% confidence interval [CI], 1.02-1.05) and a rapid plasma reagin (RPR) titer >= 1: 8 (aOR, 1.58; 95% CI, 1.03-2.43) in a multivariate analysis including age, gender, route for HIV transmission, baseline CD4 count and plasma HIV RNA load, the presence of hepatitis B surface antigen, and an RPR titer >= 1: 8. Compared with heterosexuals, the aOR for HCV seropositivity among MSM was 0.47 (95% CI, 0.31-0.72). Conclusions HCV seroprevalence among HIV-positive patients in Taiwan decreased with time, probably related to the inclusion of younger adults and more non-IDUs, and remained high among IDUs. HCV seropositivity was associated with age and an RPR titer >= 1: 8 among patients who acquired HIV through sexual contact.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1371/journal.pone.0194149
Relation:	Plos One, v.13, n.3, e0194149
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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