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| 標題: | Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1 beta-Related NLRP3 Inflammasome Activation |
| 作者: | Wang, Bour-Jr
Chiu, Hui-Wen
Lee, Yong-Lin
Li, Chia-Yi
Wang, Ying-Jan
Lee, Yu-Hsuan |
| 貢獻者: | Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Nephrol
Taipei Med Univ, Coll Med, Grad Inst Clin Med
Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth
Univ Alberta, Honors Neurosci Neurosci & Mental Hlth Inst, Fac Sci
China Med Univ, China Med Univ Hosp, Dept Med Res
Natl Cheng Kung Univ, Coll Med, Dept Food Safety Hyg & Risk Management |
| 關鍵字: | hexavalent chromium
pterostilbene
endoplasmic reticulum stress
inflammatory cytokines
NLRP3 inflammasome
allergic contact dermatitis |
| 日期: | 2018-12 |
| 上傳時間: | 2019-11-15 15:46:33 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Hexavalent chromium (Cr(VI)) is widely used in many industries but can induce contact dermatitis especially in cement industries. Many cement workers suffer from Cr(VI)-induced allergic contact dermatitis (ACD), and prevention and therapeutic strategies are still lacking. Pterostilbene (PT) is a natural compound predominantly found in blueberries. Studies indicate the potential use of PT as an effective anti-oxidative and anti-inflammatory agent. Herein, we investigated the possible mechanisms involved and whether chromium-induced ACD could be effectively inhibited by treating PT. In our in vivo study, epidermal Cr(VI) administration causes cutaneous inflammation in mice ear skin, and the pro-inflammatory cytokines, TNF-alpha, and IL-1 beta, were found in the epidermis, presenting the level of increase after Cr(VI) treatment. Meanwhile, the results of our in vitro experiment showed that apoptosis and endoplasmic reticulum (ER) stress were induced after treatment with different concentrations of Cr(VI) in HaCaT cells (human keratinocyte). Cr(VI) also induced TNF-alpha and IL-beta mRNA expressions, through the activation of the p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein kinase 2 (MK2) pathway. Notably, the severity of the skin reactions in the epicutaneous elicitation test significantly diminished when the mouse was treated with PT. Likewise, PT intervention also ameliorated the inflammation and apoptosis of HaCaT cells in vitro. Furthermore, our current findings demonstrated that the NLRP3 inflammasome could be involved in the Cr(VI)-mediated inflammation and apoptosis of ACD. Thus, interrupting this mechanism with proper nontoxic agents, such as PT, could be a new option to improve occupational chromium toxicity and hypersensitivity. |
| link: | http://dx.doi.org/10.3390/jcm7120489 |
| 關聯: | Bmc Pregnancy and Childbirth, v.7, n.12, 489 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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