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    標題: Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus
    作者: Huang, Shiow-Chyn
    Wang, Pei-Wen
    Kuo, Ping-Chung
    Hung, Hsin-Yi
    Pan, Tai-Long
    貢獻者: Chia Nan Univ Pharm & Sci, Dept Pharm
    China Med Univ, China Med Univ Hosp, Dept Med Res
    Natl Cheng Kung Univ, Sch Pharm, Coll Med
    Chang Gung Univ, Sch Tradit Chinese Med
    Chang Gung Univ Sci & Technol, Res Ctr Chinese Herbal Med, Coll Human Ecol
    Chang Gung Univ Sci & Technol, Res Ctr Food & Cosmet Safety, Coll Human Ecol
    Chang Gung Mem Hosp, Liver Res Ctr
    關鍵字: Phellinus linteus
    hepatic fibrosis
    ionone derivative
    spectroscopic and spectrometric analysis
    hepatic stellate cell
    日期: 2018-07
    上傳時間: 2019-11-15 15:46:22 (UTC+8)
    出版者: MDPI
    摘要: In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D-N (4-14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.
    link: http://dx.doi.org/10.3390/molecules23071705
    關聯: Molecules, v.23, n.7, 1705
    Appears in Collections:[藥學系(所)] 期刊論文

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