Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

doi:10.3390/molecules23071705

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/32238

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Title:	Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus
Authors:	Huang, Shiow-Chyn Wang, Pei-Wen Kuo, Ping-Chung Hung, Hsin-Yi Pan, Tai-Long
Contributors:	Chia Nan Univ Pharm & Sci, Dept Pharm China Med Univ, China Med Univ Hosp, Dept Med Res Natl Cheng Kung Univ, Sch Pharm, Coll Med Chang Gung Univ, Sch Tradit Chinese Med Chang Gung Univ Sci & Technol, Res Ctr Chinese Herbal Med, Coll Human Ecol Chang Gung Univ Sci & Technol, Res Ctr Food & Cosmet Safety, Coll Human Ecol Chang Gung Mem Hosp, Liver Res Ctr
Keywords:	Phellinus linteus hepatic fibrosis ionone derivative spectroscopic and spectrometric analysis hepatic stellate cell
Date:	2018-07
Issue Date:	2019-11-15 15:46:22 (UTC+8)
Publisher:	MDPI
Abstract:	In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D-N (4-14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.3390/molecules23071705
Relation:	Molecules, v.23, n.7, 1705
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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