The Inhibitory Effects of Djulis (Chenopodium formosanum) and Its Bioactive Compounds on Adipogenesis in 3T3-L1 Adipocytes

doi:10.3390/molecules23071780

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標題:	The Inhibitory Effects of Djulis (Chenopodium formosanum) and Its Bioactive Compounds on Adipogenesis in 3T3-L1 Adipocytes
作者:	Chyau, Charng-Cherng Chu, Chin-Chen Chen, Shih-Ying Duh, Pin-Der
貢獻者:	Hungkuang Univ, Res Inst Biotechnol Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
關鍵字:	Djulis (Chenopodium formosanum) adipogenesis lipid accumulation rutin kaempferol betanin
日期:	2018-07
上傳時間:	2019-11-15 15:46:19 (UTC+8)
出版者:	MDPI
摘要:	The aim of this study was to provide new insights into the role of the ethanolic extracts of Djulis (Chenopodium formosanum, EECF) and its bioactive compounds in preventing adipogenesis in 3T3-L1 adipocytes. The results demonstrated EECF significantly inhibited oil red O-stained material (OROSM), triglyceride levels and glycerol-3-phosphate dehydrogenase (GPDH) activity in 3T3-L1 adipocytes. The expression of the critical molecules involved in lipid synthesis such as PPAR, C/EBP and SREBP-1c was attenuated in EECF-treated cells. According to HPLC-DAD and HPLC-MS/MS analysis, rutin, kaempferol, betanin and another nine compounds were present in EECF. The suppression of lipid accumulation by rutin, kaempferol and betanin occurred by decreasing the gene expression of PPAR, C/EBP and SREBP-1c. Taken together, these findings suggest the presence of bioactive compounds in EECF may partly account for the anti-adipogenesis of EECF and EECF is therefore a potentially lipid lowering functional food.
link:	http://dx.doi.org/10.3390/molecules23071780
關聯:	Molecules, v.23, n.7, 1780
顯示於類別:	[保健營養系(所) ] 期刊論文 [ 食品科技系 ] 期刊論文

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