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    Title: The Inhibitory Effects of Djulis (Chenopodium formosanum) and Its Bioactive Compounds on Adipogenesis in 3T3-L1 Adipocytes
    Authors: Chyau, Charng-Cherng
    Chu, Chin-Chen
    Chen, Shih-Ying
    Duh, Pin-Der
    Contributors: Hungkuang Univ, Res Inst Biotechnol
    Chi Mei Med Ctr, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    Keywords: Djulis (Chenopodium formosanum)
    lipid accumulation
    Date: 2018-07
    Issue Date: 2019-11-15 15:46:19 (UTC+8)
    Publisher: MDPI
    Abstract: The aim of this study was to provide new insights into the role of the ethanolic extracts of Djulis (Chenopodium formosanum, EECF) and its bioactive compounds in preventing adipogenesis in 3T3-L1 adipocytes. The results demonstrated EECF significantly inhibited oil red O-stained material (OROSM), triglyceride levels and glycerol-3-phosphate dehydrogenase (GPDH) activity in 3T3-L1 adipocytes. The expression of the critical molecules involved in lipid synthesis such as PPAR, C/EBP and SREBP-1c was attenuated in EECF-treated cells. According to HPLC-DAD and HPLC-MS/MS analysis, rutin, kaempferol, betanin and another nine compounds were present in EECF. The suppression of lipid accumulation by rutin, kaempferol and betanin occurred by decreasing the gene expression of PPAR, C/EBP and SREBP-1c. Taken together, these findings suggest the presence of bioactive compounds in EECF may partly account for the anti-adipogenesis of EECF and EECF is therefore a potentially lipid lowering functional food.
    Relation: Molecules, v.23, n.7, 1780
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles
    [Dept. of Food Science & Technology] Periodical Articles

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