The Inhibitory Effects of Djulis (Chenopodium formosanum) and Its Bioactive Compounds on Adipogenesis in 3T3-L1 Adipocytes

doi:10.3390/molecules23071780

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/32237

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Title:	The Inhibitory Effects of Djulis (Chenopodium formosanum) and Its Bioactive Compounds on Adipogenesis in 3T3-L1 Adipocytes
Authors:	Chyau, Charng-Cherng Chu, Chin-Chen Chen, Shih-Ying Duh, Pin-Der
Contributors:	Hungkuang Univ, Res Inst Biotechnol Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
Keywords:	Djulis (Chenopodium formosanum) adipogenesis lipid accumulation rutin kaempferol betanin
Date:	2018-07
Issue Date:	2019-11-15 15:46:19 (UTC+8)
Publisher:	MDPI
Abstract:	The aim of this study was to provide new insights into the role of the ethanolic extracts of Djulis (Chenopodium formosanum, EECF) and its bioactive compounds in preventing adipogenesis in 3T3-L1 adipocytes. The results demonstrated EECF significantly inhibited oil red O-stained material (OROSM), triglyceride levels and glycerol-3-phosphate dehydrogenase (GPDH) activity in 3T3-L1 adipocytes. The expression of the critical molecules involved in lipid synthesis such as PPAR, C/EBP and SREBP-1c was attenuated in EECF-treated cells. According to HPLC-DAD and HPLC-MS/MS analysis, rutin, kaempferol, betanin and another nine compounds were present in EECF. The suppression of lipid accumulation by rutin, kaempferol and betanin occurred by decreasing the gene expression of PPAR, C/EBP and SREBP-1c. Taken together, these findings suggest the presence of bioactive compounds in EECF may partly account for the anti-adipogenesis of EECF and EECF is therefore a potentially lipid lowering functional food.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.3390/molecules23071780
Relation:	Molecules, v.23, n.7, 1780
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles [Dept. of Food Science & Technology] Periodical Articles

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