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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32203

    標題: The Risk of Traumatic Brain Injury Occurring Among Patients with Parkinson Disease: A 14-Year Population-Based Study
    作者: Nyam, Tee-Tau Eric
    Ho, Chung-Han
    Wang, Yu-Lin
    Lim, Sher-Wei
    Wang, Jhi-Joung
    Chio, Chung-Ching
    Kuo, Jinn-Rung
    Wang, Che-Chuan
    貢獻者: Chi Mei Med Ctr, Dept Neurosurg
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Med Ctr, Dept Rehabil
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Chi Mei Med Ctr, Dept Neurosurg
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
    Min Hwei Coll Hlth Care Management, Dept Nursing
    關鍵字: National Health Insurance Research Database
    Parkinson disease
    Propensity score
    Traumatic brain injury
    日期: 2018-05
    上傳時間: 2019-11-15 15:45:03 (UTC+8)
    摘要: BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. METHODS: The study selected 6076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio of TBI adjusted with the potential confounding factors. RESULTS: The incidence of TBI in patients with PD (2.57%) and compared cohorts (1.81%) was significantly different (P = 0.0007). Patients with PD had a higher risk of TBI (hazard ratio, 1.63; 95% confidence interval, 1.32-2.01) compared with the general population. Patients with PD with TBI incidence had a higher Charlson Comorbidity Index than did the general population with TBI (P < 0.0001). Fall is the major cause of TBI in patients with PD. CONCLUSIONS: This study shows that patients with PD have a high risk of TBI, and the major cause of TBI in patients with PD is fall.
    link: http://dx.doi.org/10.1016/j.wneu.2018.02.027
    關聯: World Neurosurgery, v.113, pp.E328-E335
    Appears in Collections:[醫務管理系(所)] 期刊論文

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