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https://ir.cnu.edu.tw/handle/310902800/32203
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| 標題: | The Risk of Traumatic Brain Injury Occurring Among Patients with Parkinson Disease: A 14-Year Population-Based Study |
| 作者: | Nyam, Tee-Tau Eric
Ho, Chung-Han
Wang, Yu-Lin
Lim, Sher-Wei
Wang, Jhi-Joung
Chio, Chung-Ching
Kuo, Jinn-Rung
Wang, Che-Chuan |
| 貢獻者: | Chi Mei Med Ctr, Dept Neurosurg
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Dept Rehabil
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Chi Mei Med Ctr, Dept Neurosurg
Southern Taiwan Univ Sci & Technol, Dept Biotechnol
Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
Min Hwei Coll Hlth Care Management, Dept Nursing |
| 關鍵字: | National Health Insurance Research Database
Parkinson disease
Propensity score
Traumatic brain injury |
| 日期: | 2018-05 |
| 上傳時間: | 2019-11-15 15:45:03 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE INC |
| 摘要: | BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. METHODS: The study selected 6076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio of TBI adjusted with the potential confounding factors. RESULTS: The incidence of TBI in patients with PD (2.57%) and compared cohorts (1.81%) was significantly different (P = 0.0007). Patients with PD had a higher risk of TBI (hazard ratio, 1.63; 95% confidence interval, 1.32-2.01) compared with the general population. Patients with PD with TBI incidence had a higher Charlson Comorbidity Index than did the general population with TBI (P < 0.0001). Fall is the major cause of TBI in patients with PD. CONCLUSIONS: This study shows that patients with PD have a high risk of TBI, and the major cause of TBI in patients with PD is fall. |
| link: | http://dx.doi.org/10.1016/j.wneu.2018.02.027 |
| 關聯: | World Neurosurgery, v.113, pp.E328-E335 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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