The Risk of Traumatic Brain Injury Occurring Among Patients with Parkinson Disease: A 14-Year Population-Based Study

doi:10.1016/j.wneu.2018.02.027

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Title:	The Risk of Traumatic Brain Injury Occurring Among Patients with Parkinson Disease: A 14-Year Population-Based Study
Authors:	Nyam, Tee-Tau Eric Ho, Chung-Han Wang, Yu-Lin Lim, Sher-Wei Wang, Jhi-Joung Chio, Chung-Ching Kuo, Jinn-Rung Wang, Che-Chuan
Contributors:	Chi Mei Med Ctr, Dept Neurosurg Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Rehabil Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Chi Mei Med Ctr, Dept Neurosurg Southern Taiwan Univ Sci & Technol, Dept Biotechnol Southern Taiwan Univ Sci & Technol, Ctr Gen Educ Min Hwei Coll Hlth Care Management, Dept Nursing
Keywords:	National Health Insurance Research Database Parkinson disease Propensity score Traumatic brain injury
Date:	2018-05
Issue Date:	2019-11-15 15:45:03 (UTC+8)
Publisher:	ELSEVIER SCIENCE INC
Abstract:	BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. METHODS: The study selected 6076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio of TBI adjusted with the potential confounding factors. RESULTS: The incidence of TBI in patients with PD (2.57%) and compared cohorts (1.81%) was significantly different (P = 0.0007). Patients with PD had a higher risk of TBI (hazard ratio, 1.63; 95% confidence interval, 1.32-2.01) compared with the general population. Patients with PD with TBI incidence had a higher Charlson Comorbidity Index than did the general population with TBI (P < 0.0001). Fall is the major cause of TBI in patients with PD. CONCLUSIONS: This study shows that patients with PD have a high risk of TBI, and the major cause of TBI in patients with PD is fall.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1016/j.wneu.2018.02.027
Relation:	World Neurosurgery, v.113, pp.E328-E335
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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