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| 標題: | Simultaneous three Enterobacteriaceae with different bla (NDM-1)-encoding plasmids in a patient transferred from mainland China to Taiwan |
| 作者: | Lai, Chih-Cheng
Chen, Chi-Chung
Lu, Ying-Chen
Chen, Hung-Jui
Su, Bo-An
Weng, Tzu-Chieh
Chiu, Yu-Hsin
Toh, Han-Siong
Zhang, Chun-Cheng
Chiang, Shyh-Ren
Chuang, Yin-Ching
Tang, Hung-Jen |
| 貢獻者: | Chi Mei Med Ctr, Dept Intens Care Med
Chi Mei Med Ctr, Dept Med Res
Natl Chiayi Univ, Dept Food Sci
Chi Mei Med Ctr, Dept Med
Chi Mei Med Ctr, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr |
| 關鍵字: | carbapenem-resistant Enterobacteriaceae
NDM-1
K. pneumoniae
E. coli
Citrobacter
plasmid |
| 日期: | 2018 |
| 上傳時間: | 2019-11-15 15:43:55 (UTC+8) |
| 出版者: | DOVE MEDICAL PRESS LTD |
| 摘要: | New-Delhi metallo-beta-lactamase 1 (NDM-1) Enterobacteriaceae are increasing worldwide. Herein, we describe a single patient who carried three unusual NDM-1 carbapenem-resistant Enterobacteriaceae - Enterobacter cloacae (E. cloacae) yielded from a urine specimen and Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E. cola) from stool specimens. For E. cloacae, its bla (NDM-1)-encoding plasmid was pKP04NDM with a size of similar to 54 kb replicons with an IncN backbone. For K. pneumoniae, its bla (NDM-1)-encoding plasmid was pNDM-BTR with a size of similar to 59.6 kb and belonged to lncN. For E. coli, its main bla (NDM-1)-encoding plasmid was pIMP-HK1500, and the NDM-1 gene was obtained from a part of pNDM-BTR (8439 bp). These three clinical strains are reported for the first time and are assumed to be imported from mainland China to Taiwan. The three different plasmids were never reported in K. pneumoniae, E. coli, and Citrobacter spp before. Owing to their associated multidrug resistance, appropriate measures of periodic, targeted surveillance, and development of new antimicrobial agents are urgently needed. |
| link: | http://dx.doi.org/10.2147/IDR.S179024 |
| 關聯: | Infection and Drug Resistance, v.11, pp.2555-2560 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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