Simultaneous three Enterobacteriaceae with different bla (NDM-1)-encoding plasmids in a patient transferred from mainland China to Taiwan

doi:10.2147/IDR.S179024

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/32178

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標題:	Simultaneous three Enterobacteriaceae with different bla (NDM-1)-encoding plasmids in a patient transferred from mainland China to Taiwan
作者:	Lai, Chih-Cheng Chen, Chi-Chung Lu, Ying-Chen Chen, Hung-Jui Su, Bo-An Weng, Tzu-Chieh Chiu, Yu-Hsin Toh, Han-Siong Zhang, Chun-Cheng Chiang, Shyh-Ren Chuang, Yin-Ching Tang, Hung-Jen
貢獻者:	Chi Mei Med Ctr, Dept Intens Care Med Chi Mei Med Ctr, Dept Med Res Natl Chiayi Univ, Dept Food Sci Chi Mei Med Ctr, Dept Med Chi Mei Med Ctr, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
關鍵字:	carbapenem-resistant Enterobacteriaceae NDM-1 K. pneumoniae E. coli Citrobacter plasmid
日期:	2018
上傳時間:	2019-11-15 15:43:55 (UTC+8)
出版者:	DOVE MEDICAL PRESS LTD
摘要:	New-Delhi metallo-beta-lactamase 1 (NDM-1) Enterobacteriaceae are increasing worldwide. Herein, we describe a single patient who carried three unusual NDM-1 carbapenem-resistant Enterobacteriaceae - Enterobacter cloacae (E. cloacae) yielded from a urine specimen and Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E. cola) from stool specimens. For E. cloacae, its bla (NDM-1)-encoding plasmid was pKP04NDM with a size of similar to 54 kb replicons with an IncN backbone. For K. pneumoniae, its bla (NDM-1)-encoding plasmid was pNDM-BTR with a size of similar to 59.6 kb and belonged to lncN. For E. coli, its main bla (NDM-1)-encoding plasmid was pIMP-HK1500, and the NDM-1 gene was obtained from a part of pNDM-BTR (8439 bp). These three clinical strains are reported for the first time and are assumed to be imported from mainland China to Taiwan. The three different plasmids were never reported in K. pneumoniae, E. coli, and Citrobacter spp before. Owing to their associated multidrug resistance, appropriate measures of periodic, targeted surveillance, and development of new antimicrobial agents are urgently needed.
link:	http://dx.doi.org/10.2147/IDR.S179024
關聯:	Infection and Drug Resistance, v.11, pp.2555-2560
Appears in Collections:	[保健營養系(所) ] 期刊論文

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