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    Title: Simultaneous three Enterobacteriaceae with different bla (NDM-1)-encoding plasmids in a patient transferred from mainland China to Taiwan
    Authors: Lai, Chih-Cheng
    Chen, Chi-Chung
    Lu, Ying-Chen
    Chen, Hung-Jui
    Su, Bo-An
    Weng, Tzu-Chieh
    Chiu, Yu-Hsin
    Toh, Han-Siong
    Zhang, Chun-Cheng
    Chiang, Shyh-Ren
    Chuang, Yin-Ching
    Tang, Hung-Jen
    Contributors: Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Med Res
    Natl Chiayi Univ, Dept Food Sci
    Chi Mei Med Ctr, Dept Med
    Chi Mei Med Ctr, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Keywords: carbapenem-resistant Enterobacteriaceae
    K. pneumoniae
    E. coli
    Date: 2018
    Issue Date: 2019-11-15 15:43:55 (UTC+8)
    Abstract: New-Delhi metallo-beta-lactamase 1 (NDM-1) Enterobacteriaceae are increasing worldwide. Herein, we describe a single patient who carried three unusual NDM-1 carbapenem-resistant Enterobacteriaceae - Enterobacter cloacae (E. cloacae) yielded from a urine specimen and Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E. cola) from stool specimens. For E. cloacae, its bla (NDM-1)-encoding plasmid was pKP04NDM with a size of similar to 54 kb replicons with an IncN backbone. For K. pneumoniae, its bla (NDM-1)-encoding plasmid was pNDM-BTR with a size of similar to 59.6 kb and belonged to lncN. For E. coli, its main bla (NDM-1)-encoding plasmid was pIMP-HK1500, and the NDM-1 gene was obtained from a part of pNDM-BTR (8439 bp). These three clinical strains are reported for the first time and are assumed to be imported from mainland China to Taiwan. The three different plasmids were never reported in K. pneumoniae, E. coli, and Citrobacter spp before. Owing to their associated multidrug resistance, appropriate measures of periodic, targeted surveillance, and development of new antimicrobial agents are urgently needed.
    Relation: Infection and Drug Resistance, v.11, pp.2555-2560
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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