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https://ir.cnu.edu.tw/handle/310902800/32163
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| 標題: | Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan |
| 作者: | Huang, Hung-Sheng
Ho, Chung-Han
Weng, Shih-Feng
Hsu, Chien-Chin
Wang, Jhi-Joung
Su, Shih-Bin
Lin, Hung-Jung
Huang, Chien-Cheng |
| 貢獻者: | Chi Mei Med Ctr, Dept Emergency Med
Chi Mei Med Ctr, Dept Occupat Med
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat
Southern Taiwan Univ Sci & Technol, Dept Biotechnol
Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management
Chi Mei Med Ctr, Dept Med Res
Taipei Med Univ, Dept Emergency Med
Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth
Southern Taiwan Univ Sci & Technol, Bachelor Program Senior Serv
Chi Mei Med Ctr, Dept Geriatr & Gerontol |
| 關鍵字: | Acetaminophen
Long-term
Mortality
Poisoning |
| 日期: | 2018-01-08 |
| 上傳時間: | 2019-11-15 15:43:20 (UTC+8) |
| 出版者: | BIOMED CENTRAL LTD |
| 摘要: | Background: The long-term mortality of acetaminophen (APAP) poisoning has not yet been well studied; hence, we conducted this study to gain understanding of this issue. Methods: We conducted a nationwide population-based cohort study by identifying 3235 participants with APAP poisoning and 9705 participants without APAP poisoning in Taiwan between 2003 and 2012 in the Nationwide Poisoning Database and Longitudinal Health Insurance Database 2000. Participants with APAP poisoning and control subjects were compared for the risk of all-cause mortality by follow-up until 2013. Results: Two hundred forty-one participants with APAP poisoning (7.5%) and ninety-four control subjects (1.0%) died during the follow-up. Participants with APAP poisoning had a higher risk of all-cause mortality than the control subjects (incidence rate ratio [IRR], 8.1; 95% confidence interval [CI], 6.3-10.2), especially in the subgroup aged 20 years and younger (IRR, 27.3; 95% CI, 3.5-215.5) and in the first 12 months after poisoning (IRR, 16.0; 95% CI, 9.9-25.7). The increased risk of all-cause mortality was found even up to 2 years after the index poisoning. Conclusion: APAP poisoning was associated with increased long-term mortality. Early referral for intensive aftercare and associated interventions are suggested; however, further studies of the method are needed for clarification. |
| link: | http://dx.doi.org/10.1186/s13049-017-0468-8 |
| 關聯: | Journal of Experimental & Clinical Cancer Research, v.26, 5 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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